An indolent B-cell lymphoma with t(2;8)(p12;q24) abnormality and absence of C-MYC amplification and TP53 deletion. A new variant?
| Autor: | Anil Potti, Mark C. Ingebretson, M.V. Dayton, Michael Goodell, Sugandhi A. Tharapel, Amit Panwalkar, Syed Mehdi |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Cancer Research Lymphoma B-Cell Genes myc Lymphoproliferative disorders Chromosomal translocation Translocation Genetic CD19 Immunophenotyping Genetics medicine Humans IL-2 receptor B-cell lymphoma Molecular Biology In Situ Hybridization Fluorescence Aged biology Gene Amplification Genes p53 medicine.disease Molecular biology Lymphoma Chromosomes Human Pair 2 Karyotyping Immunology biology.protein CD5 Tomography X-Ray Computed Chromosomes Human Pair 8 |
| Zdroj: | Cancer Genetics and Cytogenetics. 144:76-79 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/s0165-4608(02)00931-7 |
| Popis: | The translocation between chromosomes 2 and 8, t(2;8), is well known for its strong association with high-grade Burkitt lymphoma. However, the significance of this translocation in indolent lymphoproliferative disorders is not clear. We present the case of a 75-year-old white male with left upper quadrant abdominal pain, splenomegaly, and an elevated white cell count of 30.3×10 9 cells/L (84% large lymphoid cells with scanty cytoplasm and prominent central nucleoli). Immunophenotyping revealed a clonal B-cell population coexpressing CD5, CD19, and CD20 with weak CD23 and CD25 and very weak, restricted, surface λ. The cytogenetic analysis showed all 20 cells with t(2;8)(p12;q24.3). In addition, four of the 20 cells also showed a second translocation: t(12;17)(p13;q21). Molecular analysis using c-myc and p53 probes showed normal results with no indication of amplification of C-MYC or deletion of TP53 . The patient was managed as an indo-lent/low-grade lymphoproliferative disorder with excellent response to eight cycles of fludarabine. |
| Databáze: | OpenAIRE |
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