Bidirectional synthesis of the IJK fragment of ciguatoxin CTX3C by sequential double ring-closing metathesis and Tsuji-Trost allylation

Autor:	Michael Popadynec, Helen Gibbard, J. Stephen Clark
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Letter 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry 010402 general chemistry Metathesis 01 natural sciences Biochemistry Enol 0104 chemical sciences Double ring chemistry.chemical_compound Fragment (logic) Alcohol oxidation Ciguatoxin CTX3C Physical and Theoretical Chemistry
Zdroj:	Organic Letters
ISSN:	1523-7060
Popis:	A novel four-step bidirectional strategy has been used to synthesize the IJK fragment of the marine polyether natural product CTX3C from a simple monocyclic precursor in a concise and efficient manner. The four-step bidirectional sequence involves ring-closing metathesis, alcohol oxidation, enol carbonate formation, and palladium-mediated Tsuji-Trost allylation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91fc538534040fee821f68e9641b850 https://eprints.gla.ac.uk/214094/1/214094.pdf Zobrazit plný text záznamu