Corneal Confocal Microscopy detects a Reduction in Corneal Endothelial Cells and Nerve Fibres in Patients with Acute Ischemic Stroke

Autor:	Rami Qahwaji, Adnan Khan, Muhammad Faisal Wadiwala, Shumoos Al-Fahdawi, Rayaz A. Malik, Ashfaq Shuaib, Faheem Sartaj, Naveed Akhtar, Blessy Babu, Hamad Almuhannadi, Georgios Ponirakis, Saadat Kamran, Ioannis N. Petropoulos
Jazyk:	angličtina
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Cell lcsh:Medicine Cell Count 030204 cardiovascular system & hematology Article Brain Ischemia law.invention Cornea 03 medical and health sciences Nerve Fibers 0302 clinical medicine Confocal microscopy law Ophthalmology Diabetes mellitus medicine Humans In patient Prospective Studies Endothelial dysfunction Prospective cohort study lcsh:Science Triglycerides Microscopy Confocal Multidisciplinary business.industry lcsh:R Case-control study Endothelial Cells Middle Aged medicine.disease eye diseases Stroke Endothelial stem cell medicine.anatomical_structure Diabetes Mellitus Type 2 Case-Control Studies Linear Models Female lcsh:Q sense organs business 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) Scientific Reports
ISSN:	2045-2322
Popis:	Endothelial dysfunction and damage underlie cerebrovascular disease and ischemic stroke. We undertook corneal confocal microscopy (CCM) to quantify corneal endothelial cell and nerve morphology in 146 patients with an acute ischemic stroke and 18 age-matched healthy control participants. Corneal endothelial cell density was lower (P P P P P P = 0.001) were lower in patients with acute ischemic stroke compared to controls. Corneal endothelial cell density, cell area and cell perimeter correlated with corneal nerve fiber density (P = 0.033, P = 0.014, P = 0.011) and length (P = 0.017, P = 0.013, P = 0.008), respectively. Multiple linear regression analysis showed a significant independent association between corneal endothelial cell density, area and perimeter with acute ischemic stroke and triglycerides. CCM is a rapid non-invasive ophthalmic imaging technique, which could be used to identify patients at risk of acute ischemic stroke.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91f3e440c63ac15ac6a685ec5e287a2 http://link.springer.com/article/10.1038/s41598-018-35298-3 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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