Tumours of the thymus: a cohort study of prognostic factors from the European Society of Thoracic Surgeons database
| Autor: | Andrew G Nicholson, Nuria M. Novoa, Moishe Liberman, Alex Arame, Christophoros N. Foroulis, Federico Venuta, David Gómez de Antonio, Frank C. Detterbeck, Marco Anile, Majed Refai, AlKattan Khaled, Wojciech Zurek, Dirk Van Raemdonck, Geoffrey Brioude, Pascal Thomas, Maurizio Mancuso, Mario Nosotti, Marco Scarci, Enrico Ruffini, Robert J. Cerfolio, Alessandro Brunelli, Andrea Evangelista, Eric Lim, Bernhard Moser, Alberto Terzi, Caterina Casadio, Loic Lang-Lazdunski, Pier Luigi Filosso, Alper Toker, Hans Van Veer, Paolo Carbognani, Walter Weder, Luca Voltolini, Giovanni Donati, Nasser K. Altorki, Cengiz Gebitekin, Salvatore Saita, Erino A. Rendina, Alberto Oliaro, Gaetano Rocco, Jan Schutzner, Cosimo Lequaglie, Shaf Keshavjee, Kemp H. Kernstine |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Myasthenia gravis Neuroendocrine thymic tumours Staging Surgery Thymic carcinoma Thymoma Aged Databases Factual Female Humans Middle Aged Myasthenia Gravis Neoplasm Recurrence Local Neoplasm Staging Neuroendocrine Tumors Prognosis Retrospective Studies Survival Analysis Thymus Neoplasms Cardiology and Cardiovascular Medicine Medicine (all) Thoracic Gastroenterology Databases Internal medicine medicine Adjuvant therapy Cumulative incidence Stage (cooking) Factual Survival analysis business.industry Hazard ratio Retrospective cohort study General Medicine medicine.disease Neoplasm Recurrence Local business |
| Popis: | OBJECTIVES: A retrospective database was developed by the European Society of Thoracic Surgeons, collecting patients submitted to surgery for thymic tumours to analyse clinico-pathological prognostic predictors. METHODS: A total of 2151 incident cases from 35 institutions were collected from 1990 to 2010. Clinical-pathological characteristics were analysed, including age, gender, associated myasthenia gravis stage (Masaoka), World Health Organization histology, type of thymic tumour [thymoma, thymic carcinoma (TC), neuroendocrine thymic tumour (NETT)], type of resection (complete/incomplete), tumour size, adjuvant therapy and recurrence. Primary outcome was overall survival (OS); secondary outcomes were the proportion of incomplete resections, disease-free survival and the cumulative incidence of recurrence (CIR). RESULTS: A total of 2030 patients were analysed for OS (1798 thymomas, 191 TCs and 41 NETTs). Ten-year OS was 0.73 (95% confidence interval 0.69–0.75). Complete resection (R0) was achieved in 88% of the patients. Ten-year CIR was 0.12 (0.10–0.15). Predictors of shorter OS were increased age (P |
| Databáze: | OpenAIRE |
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