Cellular locomotion using environmental topography
Autor: | Florian Gaertner, Andrew Callan-Jones, Saren Tasciyan, Anne Reversat, Raphaël Voituriez, Matthieu Piel, Ingrid de Vries, Julian Stopp, Juan Aguilera, Robert Hauschild, Jack Merrin, Miroslav Hons, Michael Sixt |
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Rok vydání: | 2020 |
Předmět: |
0303 health sciences
Multidisciplinary biology Chemistry fungi Shear force Integrin Adhesion Actin cytoskeleton Transmembrane protein Coupling (electronics) 03 medical and health sciences 0302 clinical medicine Biophysics biology.protein Cell adhesion 030217 neurology & neurosurgery Actin 030304 developmental biology |
Zdroj: | Nature |
ISSN: | 1476-4687 0028-0836 |
Popis: | Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the environment. While force coupling is usually mediated by transmembrane adhesion receptors, especially those of the integrin family, amoeboid cells such as leukocytes can migrate extremely fast despite very low adhesive forces1. Here we show that leukocytes cannot only migrate under low adhesion but can also transmit forces in the complete absence of transmembrane force coupling. When confined within three-dimensional environments, they use the topographical features of the substrate to propel themselves. Here the retrograde flow of the actin cytoskeleton follows the texture of the substrate, creating retrograde shear forces that are sufficient to drive the cell body forwards. Notably, adhesion-dependent and adhesion-independent migration are not mutually exclusive, but rather are variants of the same principle of coupling retrograde actin flow to the environment and thus can potentially operate interchangeably and simultaneously. As adhesion-free migration is independent of the chemical composition of the environment, it renders cells completely autonomous in their locomotive behaviour. |
Databáze: | OpenAIRE |
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