Stable and pH-Sensitive Nanogels Prepared by Self-Assembly of Chitosan and Ovalbumin
Autor: | Shaoyong Yu, Ming Jiang, Jinhua Hu, Ping Yao, Xiaoyun Pan |
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Rok vydání: | 2006 |
Předmět: |
Ovalbumin
Nanoparticle Microscopy Atomic Force Chitosan chemistry.chemical_compound Hydrophily Polymer chemistry Electrochemistry Scattering Radiation General Materials Science Spectroscopy biology Surfaces and Interfaces Hydrogen-Ion Concentration Condensed Matter Physics Microscopy Fluorescence chemistry Chemical engineering biology.protein Ph range Nanoparticles Spectrophotometry Ultraviolet Self-assembly Macromolecule Nanogel |
Zdroj: | Langmuir. 22:2754-2759 |
ISSN: | 1520-5827 0743-7463 |
Popis: | Two natural macromolecules, chitosan and ovalbumin, were used to produce nanogels by a new, green, and convenient method. Chitosan and ovalbumin solutions were mixed; the pH of the resulting solution was adjusted; and the solution was successively stirred and heated. After that, ovalbumin gelled forming nanospheres. The chitosan chains are supposed to be partly trapped in the nanogel core upon heating because of the electrostatic attractions between chitosan and ovalbumin, while the rest of the chitosan chains should form the shell of the nanogels. The nanogels did not change the size distribution after long-time storage and did not dissociate in the pH range of 2-10.5. The dispersibility, size, and hydrophobicity/hydrophilicity of the nanogels are pH-dependent. The nanogels are good candidates for cosmetic and pharmaceutical applications. |
Databáze: | OpenAIRE |
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