Tannic acid prevents post-weaning diarrhea by improving intestinal barrier integrity and function in weaned piglets

Autor: Junqiu Luo, Ping Zheng, Yanyan Song, Xiangbing Mao, Hui Yan, Daiwen Chen, Huifen Wang, Jun He, Bing Yu, Zhiqing Huang, Jie Yu, Yuheng Luo, Quyuan Wang
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Journal of Animal Science and Biotechnology, Vol 11, Iss 1, Pp 1-11 (2020)
Journal of Animal Science and Biotechnology
ISSN: 2049-1891
DOI: 10.1186/s40104-020-00496-5
Popis: Background Tannic acid (TA) is potential to reduce diarrhea in weaning pigs, but knowledge about the influence of TA on intestinal barrier integrity and function is still scarce. This experiment was conducted to investigate the effects of dietary TA supplementation on growth performance, diarrhea rate, intestinal barrier integrity and function of weaned pigs. Methods A total of 108 crossbred (Duroc × Landrace × Yorkshire) piglets, with an initial average body weight of 6.60 ± 0.27 kg, were allotted to 3 groups (6 pigs/pen and 6 replicates/group) in a randomized complete block design according to their gender and body weight. Piglets were fed the basal diet with 0 (control, CON), 0.2% and 1.0% TA, respectively. The trial lasted for 28 d. Results Compared with the CON group, dietary 0.2% and 1.0% TA supplementation didn’t affect ADFI, ADG and F:G (P > 0.05), but reduced diarrhea rate, diarrhea index and diarrhea score of piglets (P P P P P P P OCLN) mRNA and 0.2% TA group had higher zonula occludens-2 (ZO-2) level (P OCLN mRNA levels in the jejunum (P ZO-1) mRNA levels in the ileum (P Conclusion In conclusion, dietary supplementation of 0.2% or 1.0% TA could effectively alleviate post-weaning diarrhea without altering growth performance in weaned piglets, which might be achieved by improving intestinal barrier integrity and function.
Databáze: OpenAIRE
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