CAR-T Cell Therapy for Solid Tumors: Are we Still That Far? a Systematic Review of Literature

Autor:	Aya Karam, Georges Mjaess, Nieves Martinez Chanza, Fouad Aoun, George Bou Kheir, Hadi Younes, Hanane Kazzi, Simone Albisinni, Thierry Roumeguère
Rok vydání:	2022
Předmět:	Male Cancer Research Receptors Chimeric Antigen chimeric antigen receptor CAR T-cell therapy precision medicine T-Lymphocytes Receptors Antigen T-Cell Cell- and Tissue-Based Therapy General Medicine solid tumors Immunotherapy Adoptive Settore MED/24 Oncology Humans Prospective Studies Gastrointestinal Neoplasms
Zdroj:	Cancer investigation. 40(10)
ISSN:	1532-4192
Popis:	This systematic review aims to assess all the prospective studies published to date on the efficacy of CAR-T cell therapy in solid tumors. Databases searched were PubMed and Google Scholar from inception through May 1st 2021. Search query was (Chimeric antigen receptor) or (CAR-T) or (T-CAR). Twenty-nine prospective studies (265 patients) were included. Most published clinical trials are phase I. Clinical benefit was 100% in epithelial ovarian cancer, 70-82% in gastrointestinal tumors, 79% in mesothelioma, 63% in small-cell lung cancer, 24-67% in sarcoma, 50-62% in prostate cancer, and 45-50% in central nervous system tumors. No serious CAR-T cell specific serious toxicities were noted.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9122a1528833ddeae7a125807c65211 https://pubmed.ncbi.nlm.nih.gov/36102932 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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