Bacterial Quorum Sensing During Infection
| Autor: | Stephen P. Diggle, Alexander D. Klementiev, Marvin Whiteley, Sheyda Azimi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Genetics
Bacteria Virulence Virulence Factors Quorum Sensing Pathogenic bacteria Bacterial Infections Gene Expression Regulation Bacterial Biology medicine.disease_cause biology.organism_classification Microbiology Quorum sensing Disease Models Animal Antibiotic resistance Bacterial Proteins medicine Animals Cell-cell signaling Pathogen Function (biology) Signal Transduction |
| Zdroj: | Annual review of microbiology. 74 |
| ISSN: | 1545-3251 |
| Popis: | Bacteria are highly interactive and possess an extraordinary repertoire of intercellular communication and social behaviors, including quorum sensing (QS). QS has been studied in detail at the molecular level, so mechanistic details are well understood in many species and are often involved in virulence. The use of different animal host models has demonstrated QS-dependent control of virulence determinants and virulence in several human pathogenic bacteria. QS also controls virulence in several plant pathogenic species. Despite the role QS plays in virulence during animal and plant laboratory-engineered infections, QS mutants are frequently isolated from natural infections, demonstrating that the function of QS during infection and its role in pathogenesis remain poorly understood and are fruitful areas for future research. We discuss the role of QS during infection in various organisms and highlight approaches to better understand QS during human infection. This is an important consideration in an era of growing antimicrobial resistance, when we are looking for new ways to target bacterial infections. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|