Community dysfunction in schizophrenia: Rate-limiting factors
| Autor: | Katerina Gamvrula, Eleni Vasiliadou, Anna Kafantari, Kostas Fokas, Petros Petrikis, Athanasios Karavatos, Mary H. Kosmidis, Vasilis P. Bozikas |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Neuropsychological Tests Severity of Illness Index Extrapyramidal symptoms Visual memory medicine Humans Attention Interpersonal Relations Psychiatry Problem Solving Biological Psychiatry Psychiatric Status Rating Scales Pharmacology Positive and Negative Syndrome Scale Cognitive flexibility Social Behavior Disorders Recognition Psychology Cognition Middle Aged medicine.disease Memory Short-Term Schizophrenia Quality of Life Female Schizophrenic Psychology medicine.symptom Verbal memory Psychology Social Adjustment Neurocognitive Psychomotor Performance Clinical psychology |
| Zdroj: | Progress in Neuro-Psychopharmacology and Biological Psychiatry. 30:463-470 |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/j.pnpbp.2005.11.017 |
| Popis: | The purpose of the present study was to investigate the impact of cognitive functioning, psychopathology, and severity of extrapyramidal side effects on community outcome in a group of Greek outpatients with schizophrenia. Participants were 40 outpatients with schizophrenia (25 men). Social adjustment was assessed with the Quality of Life Scale (QLS). Severity of symptoms of schizophrenia was measured with the Positive and Negative Syndrome Scale (PANNS), and extrapyramidal symptoms with the Extrapyramidal Symptom Rating Scale (ESRS). Finally, a battery of neuropsychological tests was administered in order to assess the following cognitive domains: executive functioning/set shifting, executive functioning/inhibition, fluency, verbal memory, visual memory, working memory, attention, visuospatial ability, and psychomotor speed/visual scanning. Total scores on the QLS were significantly correlated with negative symptoms, parkinsonism, and performance on the fluency tasks. Interpersonal relations subscale was significantly related with negative symptoms and fluency. No significant relationship was found between the Instrumental Role Functioning subscale and the PANSS, ESRS, or any cognitive domain. Scores on the Intrapsychic Foundation subscale were significantly correlated with negative symptoms and fluency. Finally, scores on the Common Objects and Activities subscale were significantly related with severity of negative symptoms, parkinsonism and visual memory. Our findings suggest that severity of negative symptoms, cognitive dysfunction, especially performance on fluency tasks and visual memory, as well as parkinsonism, are important determinants of functional outcome in schizophrenia. |
| Databáze: | OpenAIRE |
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