Impaired regeneration and no amelioration with aldose reductase inhibitor in crushed unmyelinated nerve fibers of diabetic rats
| Autor: | Masahiko Terada, Atsunori Kashiwagi, Masakazu Haneda, Kengo Maeda, Hitoshi Yasuda, Ryuichi Kikkawa, Teiji Sasaki, Yuzo Taniguchi |
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| Rok vydání: | 1999 |
| Předmět: |
Male
Tolrestat medicine.medical_specialty Nerve Crush Unmyelinated nerve fiber Naphthalenes Diabetes Mellitus Experimental Rats Sprague-Dawley chemistry.chemical_compound Nerve Fibers Aldehyde Reductase Diabetes mellitus Internal medicine medicine Animals Enzyme Inhibitors Axon biology business.industry General Neuroscience Therapeutic effect medicine.disease Aldose reductase inhibitor Nerve Regeneration Rats medicine.anatomical_structure Endocrinology chemistry Enzyme inhibitor biology.protein Sciatic nerve business medicine.drug |
| Zdroj: | NeuroReport. 10:2405-2409 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-199908020-00034 |
| Popis: | The regenerative ability of unmyelinated nerve fibers (UNFs) in diabetes and the effect of aldose reductase inhibitor (ARI) on it were ultrastructurally evaluated after sciatic nerve crush in control and untreated and tolrestat-treated streptozocin-induced diabetic rats. The density and number of UNFs were significantly increased in all groups at 5 weeks after the injury. The increase returned to the baseline level in control rats, but not in diabetic rats at 24 weeks. Although the axon size showed a marked decrease at 5 weeks and an incomplete recovery at 24 weeks in all groups, the recovery was significantly worse in diabetic than in control groups. Tolrestat did not have any effect on regeneration of UNFs in diabetes. These results suggest impaired regeneration of UNFs after nerve crush injury in diabetes and less therapeutic effect of ARI on it. |
| Databáze: | OpenAIRE |
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