Compounds with distinct targets present diverse antimicrobial and antibiofilm efficacy against candida albicans and streptococcus mutans, and combinations of compounds potentiate their effect
| Autor: | Ana Carolina Urbano de Araújo Lopes, Carmélia Isabel Vitorino Lobo, Marlise I. Klein |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
QH301-705.5 extracellular matrix Antibiofilm agents antimicrobial agents Plant Science Streptococcus mutans biofilm Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Candida albicans Biology (General) Ecology Evolution Behavior and Systematics 0303 health sciences biology 030306 microbiology Chemistry Biofilm 030206 dentistry antibiofilm agents Extracellular matrix biochemical phenomena metabolism and nutrition biology.organism_classification Antimicrobial Antimicrobial agents Corpus albicans Quorum sensing Myricetin Bacteria |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Fungi Volume 7 Issue 5 Journal of Fungi, Vol 7, Iss 340, p 340 (2021) |
| Popis: | Made available in DSpace on 2021-06-25T11:00:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-05-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Candida albicans and Streptococcus mutans interact synergistically in biofilms associated with a severe form of dental caries. Their synergism is driven by dietary sucrose. Thus, it is necessary to devise strategies to hinder the development of those biofilms and prevent cavities. Six compounds [tt-farnesol (sesquiterpene alcohol that decreases the bacterium acidogenicity and aciduricity and a quorum sensing fungal molecule), myricetin (flavonoid that interferes with S. mutans exopolysaccharides production), two 2’-hydroxychalcones and 4’-hydroxychalcone (intermediate metabolites for flavonoids), compound 1771 (inhibitor of lipoteichoic synthase in Gram-positive bacteria)] with targets in both fungus and bacterium and their products were investigated for their antimicrobial and antibiofilm activities against single-species cultures. The compounds and concentrations effective on single-species biofilms were tested alone and combined with or without fluoride to control initial and pre-formed dual-species biofilms. All the selected treatments eliminated both species on initial biofilms. In contrast, some combinations eliminated the bacterium and others the fungus in pre-formed biofilms. The combinations 4’-hydroxychalcone+tt-farnesol+myricetin, 4’-hydroxychalcone+tt-farnesol+fluoride, and all compounds together with fluoride were effective against both species in pre-formed biofilms. Therefore, combinations of compounds with distinct targets can prevent C. albicans and S. mutans dual-species biofilm build-up in vitro. Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp), Araraquara. Rua Humaitá, 1680 Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (Unesp), Araraquara. Rua Humaitá, 1680 CAPES: 001 CNPq: 141316/2020-9 CNPq: 409668/2018-4 |
| Databáze: | OpenAIRE |
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