Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review
| Autor: | Lisa M. McTeague, Joshua C. Brown, Oliver J. Mithoefer, Nicholas T. LaBate, Bashar W. Badran, William H. DeVries, Christopher W. Austelle, Logan T. Dowdle, Mark S. George, James Coatsworth |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_treatment
Anterior cingulate cortex (ACC) Biophysics Stimulation 050105 experimental psychology Article lcsh:RC321-571 Midbrain 03 medical and health sciences 0302 clinical medicine Transcutaneous auricular vagus nerve stimulation (taVNS) Medicine 0501 psychology and cognitive sciences lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry business.industry Postcentral gyrus General Neuroscience 05 social sciences fMRI Neuromodulation (medicine) Vagus nerve nervous system Influential Publication Ear stimulation Neurology (clinical) Brainstem business Neuroscience Insula 030217 neurology & neurosurgery Vagus nerve stimulation |
| Zdroj: | Focus (Am Psychiatr Publ) Brain Stimulation, Vol 11, Iss 3, Pp 492-500 (2018) |
| Popis: | Background Electrical stimulation of the auricular branch of the vagus nerve (ABVN) via transcutaneous auricular vagus nerve stimulation (taVNS) may influence afferent vagal networks. There have been 5 prior taVNS/fMRI studies, with inconsistent findings due to variability in stimulation targets and parameters. Objective We developed a taVNS/fMRI system to enable concurrent electrical stimulation and fMRI acquisition to compare the effects of taVNS in relation to control stimulation. Methods We enrolled 17 healthy adults in this single-blind, crossover taVNS/fMRI trial. Based on parameters shown to affect heart rate in healthy volunteers, participants received either left tragus (active) or earlobe (control) stimulation at 500 μs 25 HZ for 60 s (repeated 3 times over 6 min). Whole brain fMRI analysis was performed exploring the effect of: active stimulation, control stimulation, and the comparison. Region of interest analysis of the midbrain and brainstem was also conducted. Results Active stimulation produced significant increased BOLD signal in the contralateral postcentral gyrus, bilateral insula, frontal cortex, right operculum, and left cerebellum. Control stimulation produced BOLD signal activation in the contralateral postcentral gyrus. In the active vs. control contrast, tragus stimulation produced significantly greater BOLD increases in the right caudate, bilateral anterior cingulate, cerebellum, left prefrontal cortex, and mid-cingulate. Conclusion Stimulation of the tragus activates the cerebral afferents of the vagal pathway and combined with our review of the literature suggest that taVNS is a promising form of VNS. Future taVNS/fMRI studies should systematically explore various parameters and alternative stimulation targets aimed to optimize this novel form of neuromodulation. |
| Databáze: | OpenAIRE |
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