The need to shift pharmacogenetic research from candidate gene to genome-wide association studies

Autor:	David C Linskey, Derek W. Linskey, Howard L. McLeod, Jasmine A. Luzum
Rok vydání:	2021
Předmět:	Pharmacology Candidate gene Genome-wide association study Computational biology Biology Pharmacogenetics Pharmacogenomics Perspective Genetics Humans Molecular Medicine Candidate Gene Association Study Gene Genetic Association Studies Genome-Wide Association Study Genetic association
Zdroj:	Pharmacogenomics
ISSN:	1744-8042 1462-2416
DOI:	10.2217/pgs-2021-0108
Popis:	The primary research approach in pharmacogenetics has been candidate gene association studies (CGAS), but pharmacogenomic genome-wide association studies (GWAS) are becoming more common. We are now at a critical juncture when the results of those two research approaches, CGAS and GWAS, can be compared in pharmacogenetics. We analyzed publicly available databases of pharmacogenetic CGAS and GWAS (i.e., the Pharmacogenomics Knowledgebase [PharmGKB®] and the NHGRI-EBI GWAS catalog) and the vast majority of variants (98%) and genes (94%) discovered in pharmacogenomic GWAS were novel (i.e., not previously studied CGAS). Therefore, pharmacogenetic researchers are not selecting the right candidate genes in the vast majority of CGAS, highlighting a need to shift pharmacogenetic research efforts from CGAS to GWAS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9101b20c4907f692d62e584653b865f https://doi.org/10.2217/pgs-2021-0108 Zobrazit plný text záznamu