Iatrogenic Ocular Surface Diseases Occurring during and/or after Different Treatments for Ocular Tumours
| Autor: | Antonio Maestri, Pierre-Raphaël Rothschild, Federico Bernabei, Marco Pellegrini, Martina Angi, Giuseppe Giannaccare, Vito Romano, Vincenzo Scorcia |
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| Přispěvatelé: | Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), IRCCS Istituto Nazionale dei Tumori [Milano], Policlinico S. Orsola-malpighi, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Servizio sanitario regionale Emilia-Romagna, Royal Liverpool University Hospital, University of Liverpool-Royal Liverpool and Broadgreen University Hospital NHS Trust, University of Liverpool, Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université de Paris (UP), Università degli Studi 'Magna Graecia' di Catanzaro = University of Catanzaro (UMG), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Gestionnaire, Hal Sorbonne Université |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
medicine.medical_specialty genetic structures complications medicine.medical_treatment [SDV]Life Sciences [q-bio] Perforation (oil well) Brachytherapy Review Disease ocular tumours NO Keratitis Lesion 03 medical and health sciences dry eye 0302 clinical medicine medicine choroidal melanoma RC254-282 radiotherapy ocular surface ocular surface squamous neoplasia business.industry Melanoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens anti-cancer agents medicine.disease Dermatology eye diseases 3. Good health Radiation therapy [SDV] Life Sciences [q-bio] Oncology 030220 oncology & carcinogenesis 030221 ophthalmology & optometry sense organs medicine.symptom uveal melanoma business Ocular surface Anti-cancer agents Choroidal melanoma Complications Dry eye Ocular surface squamous neoplasia Ocular tumours Radiotherapy Uveal melanoma |
| Zdroj: | Cancers Cancers, MDPI, 2021, 13 (8), pp.1933. ⟨10.3390/cancers13081933⟩ Cancers, 2021, 13 (8), pp.1933. ⟨10.3390/cancers13081933⟩ Cancers, Vol 13, Iss 1933, p 1933 (2021) |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers13081933⟩ |
| Popis: | Simple Summary The ocular surface represents a finely regulated system that allows the protection of the eye. It can be affected by therapies used for the treatment of various intraocular tumours, particularly conjunctival cancers and uveal melanoma. In these conditions, treatments are chosen according to the characteristics of the lesion, and include a combination of selective surgery, anticancer eye drops, and/or radiotherapy delivered through different mechanisms. Possible side effects affecting the ocular surface range from transient dry eye or keratitis up to more severe complications such as corneal melting and perforation. These complications deserve careful evaluation for the risk of permanent sight-threatening sequelae. Physicians involved in the management of patients affected by ocular tumours should be aware of this risk in order to reach an early diagnosis and promptly set up an adequate treatment. The present review summarizes acute and chronic complications affecting the ocular surface following different therapies for the treatment of conjunctival cancers and uveal melanoma, and also reports clinical cases of representative patients who experienced these complications. Abstract The ocular surface represents a finely regulated system that allows the protection of the eye. It is particularly susceptible to different treatments for intraocular tumours, such as uveal melanoma and conjunctival cancers. Traditionally, the management of ocular tumours depends on the characteristics of the lesion, and is based on a combination of selective surgery, topical chemotherapy, and/or radiotherapy delivered through different mechanisms (e.g., charged-particle radiotherapy or brachytherapy). Possible complications involving the ocular surface range from transient dry eye disease or keratitis up to corneal melting and perforation, which in any case deserve careful evaluation for the risk of permanent sigh-threatening complications. Clinicians involved in the management of these patients must be aware of this risk, in order to reach an early diagnosis and promptly set up an adequate treatment. The present review of the literature will summarize acute and chronic complications affecting the ocular surface following different therapies for the treatment of ocular tumours. |
| Databáze: | OpenAIRE |
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