Enantioselective Radical Trifluoromethylation of Benzylic C–H Bonds via Cooperative Photoredox and Copper Catalysis

Autor:	Pin Xu, Wenzheng Fan, Pinhong Chen, Guosheng Liu
Rok vydání:	2022
Předmět:	Colloid and Surface Chemistry Stereoisomerism General Chemistry Biochemistry Copper Catalysis Hydrogen
Zdroj:	Journal of the American Chemical Society. 144:13468-13474
ISSN:	1520-5126 0002-7863
DOI:	10.1021/jacs.2c06432
Popis:	The first enantioselective radical trifluoromethylation of benzylic C-H bonds has been established by a cooperative photoredox and copper catalysis system, providing straightforward access to structurally diverse benzylic trifluoromethylation products in good yields with excellent enantioselectivities under mild conditions. Our method features a broad substrate scope and excellent functional group compatibility. Merging the cooperative photoredox catalysis with copper catalysis is essential for the reaction, where the photoredox catalysis is used for the generation of benzylic radicals from alkyl arenes through a hydrogen atom transfer process and the copper catalysis is used for the enantioselective trifluoromethylation of the benzylic radicals.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90efc852cdb0096af249e22f29e84cb https://doi.org/10.1021/jacs.2c06432 Zobrazit plný text záznamu