T2* weighted placental MRI in relation to placental histology and birth weight
| Autor: | Jens Brøndum Frøkjær, Astrid Christine Petersen, Anne Nødgaard Sørensen, Ditte Nymark Hansen, David A Peters, Marianne Munk Sinding |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Placenta Diseases Placenta Birth weight Placental dysfunction Logistic regression Andrology Pregnancy In vivo Birth Weight Humans Medicine Fetus business.industry T2* weighted MRI Obstetrics and Gynecology Placental histology Oxygenation Magnetic Resonance Imaging T2* relaxation Reproductive Medicine Placental histological examination Gestation Female business Developmental Biology |
| Zdroj: | Sinding, M, Sørensen, A, Hansen, D N, Peters, D A, Frøkjær, J B & Petersen, A C 2021, ' T2* weighted placental MRI in relation to placental histology and birth weight ', Placenta, vol. 114, pp. 52-55 . https://doi.org/10.1016/j.placenta.2021.07.304 |
| DOI: | 10.1016/j.placenta.2021.07.304 |
| Popis: | Introduction Placental dysfunction may be found among normal birth weight (BW) pregnancies, as indicated by abnormal histological findings in postnatal placental examination in some of these pregnancies. T2* weighted placental MRI provides non-invasive information on placental oxygenation and thereby placental function. The aim of this study was to investigate the correlation between placental T2*, BW and placental histology. Methods A total of 63 pregnant women underwent T2* weighted placental MRI at 15–40 week's gestation and a standardized placental histological examination (PHE). Abnormal PHE was defined by vascular malperfusion according to the Amsterdam workshop consensus. The correlation between PHE, BW z-score and T2* z-score was analyzed by logistic regression. Results Abnormal PHE was revealed in 28 pregnancies. Multiple logistic regression revealed a significant correlation between abnormal PHE and T2* z-score (OR = 0.34, p = 0.008), whereas BW z-score did not add significantly to the correlation of placental histology (OR = 0.52, p = 0.115). In BW z-score≥0, PHE was normal in 100% of pregnancies. In BW z-score ≤ −2, PHE was abnormal in 89% of pregnancies. In intermediate BW (z-score between −2 and 0), PPE was abnormal in 35% of pregnancies. In this intermediate group, placental T2* z-score was reduced (−1.52 ± 1.22 (mean SD)) when compared to normal PHE pregnancies (−0.28 ± 1.17), p = 0.006. Discussion This study demonstrates a correlation between abnormal placental histology and low placental T2* value regardless of fetal size. This indicates that T2* provides information of placental function in vivo even when fetal size is normal. This finding highlights that fetal size alone is not a valid marker of placental dysfunction. |
| Databáze: | OpenAIRE |
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