Determination of potency and paraspecific effects of Androctonus crassicauda (Olivier, 1807) antivenom against Mesobuthus gibbosus (Brullé, 1832) venom (Scorpiones: Buthidae)
| Autor: | Y. Cesaretli, S. Yakistiran, Sirri Kar, S. Adiguzel, Kadri Zafer Karaer, O. Ozkan |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
lcsh:Arctic medicine. Tropical medicine
lcsh:RC955-962 Antivenom Scorpion Venom Toxicology Mesobuthus gibbosus scorpion Buthidae lcsh:RA1190-1270 biology.animal lcsh:Zoology Potency lcsh:QL1-991 Envenomation lcsh:Toxicology. Poisons antivenom biology Traditional medicine paraspecific activity Androctonus crassicauda biology.organism_classification Infectious Diseases Animal Science and Zoology Parasitology |
| Zdroj: | Journal of Venomous Animals and Toxins including Tropical Diseases v.13 n.2 2007 The Journal of venomous animals and toxins including tropical diseases Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of Venomous Animals and Toxins including Tropical Diseases, Volume: 13, Issue: 2, Pages: 500-508, Published: 2007 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 2, Pp 500-508 (2007) |
| Popis: | Scorpion envenomation remains a real health problem in many countries. In scorpionism cases, it is often recommended that patients be treated with species-specific antivenom. Androctonus crassicauda venom has been used as antigen for antivenom production in Turkey, where this antivenom, called Turkish antivenom, has also been effective in the treatment of envenomation caused by species other than A. crassicauda. The present study aimed at determining the paraspecific effects and potency of the Turkish antivenom against Mesobuthus gibbosus (Brulle, 1832) venom. To assess the venom toxicity and the antivenom efficacy, we determined the Minimum Lethal Dose (MLD) and the Minimum Effective Dose (MED) instead of LD50 and ED50, respectively. Androctonus crassicauda antivenom was capable of neutralizing M. gibbosus venom (20 MLD). This was the first study indicating that A. crassicauda antivenom can be used for the treatment of Mesobuthus gibbosus stings, especially in Aegean Region, Turkey. |
| Databáze: | OpenAIRE |
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