Funicone-related Compounds, Potentiators of Antifungal Miconazole Activity, Produced by Talaromyces flavus FKI-0076
| Autor: | Noriko Tabata, Yuichi Yamaguchi, Masayoshi Arai, Hiroshi Tomoda, Takako Okuda, Haiyan Wang, Satoshi Omura, Rokuro Masuma |
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| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
Antifungal Agents Miconazole biology Chemistry Talaromyces Stereochemistry Drug Synergism Biological activity Microbial Sensitivity Tests biology.organism_classification High-performance liquid chromatography Corpus albicans chemistry.chemical_compound Column chromatography Candida albicans Fermentation Drug Discovery medicine Benzoic acid medicine.drug |
| Zdroj: | The Journal of Antibiotics. 55:172-180 |
| ISSN: | 1881-1469 0021-8820 |
| DOI: | 10.7164/antibiotics.55.172 |
| Popis: | Talaromyces flavus FKI-0076, a soil isolate, was found to produce compounds which reinforce the anti-Candida albicans activity of miconazole. Four structurally related compounds, a novel one, designated actofunicone, and the knowns deoxyfunicone, vermistatin and NG-012, were isolated from the culture broth by solvent extraction, ODS column chromatography and HPLC. The structure of actofunicone was elucidated as benzoic acid, 3,5-dimethoxy-2-[[4-oxo-6-(2-acetyloxy propyl)-4H-pyran-3-yl]carbonyl]-, methyl ester by various spectroscopic analyses including NMR experiments. These compounds potentiated the anti-C. albicans activity of miconazole, decreasing the IC50 value of miconazole from 19 microM to 1.6 approximately 3.7 microM in the presence of the funicones. |
| Databáze: | OpenAIRE |
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