Radical Borylative Cyclization of Isocyanoarenes with N-Heterocyclic Carbene Borane: Synthesis of Borylated Aza-arenes

Autor:	Jia-Qiang Wu, Zhi-Shu Huang, Ji-Lin Li, Yao Liu, Xu-Ge Liu, Qingjiang Li, Honggen Wang
Rok vydání:	2021
Předmět:	Reaction conditions Alternative methods 010405 organic chemistry Organic Chemistry Borane 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Organic synthesis Physical and Theoretical Chemistry Carbene
Zdroj:	Organic Letters. 23:1891-1897
ISSN:	1523-7052 1523-7060
Popis:	Borylated aza-arenes are of great importance in the area of organic synthesis. A radical borylative cyclization of isocyanoarenes with N-heterocyclic carbene borane (NHC-BH3) under metal-free conditions was developed. The reaction allows the efficient assembly of several types of borylated aza-arenes (phenanthridines, benzothiazoles, etc.), which are difficult to access using alternative methods. Mild reaction conditions, a good functional-group tolerance, and generally good efficiencies were observed. The utility of these products is demonstrated, and the mechanism is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e908c0c55306703bbd611178f08eb3cc https://doi.org/10.1021/acs.orglett.1c00309 Zobrazit plný text záznamu