Effect of Oral Contraceptives on Glucuronyl Transferase
| Autor: | R. F. Piper, Janice Cam, Tom Hargreaves |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Population Glucuronates In Vitro Techniques Ethinyl Estradiol General Biochemistry Genetics and Molecular Biology Lynestrenol Ethynodiol Diacetate Phenols Transferases Internal medicine medicine Animals Endocrine system education Pathological education.field_of_study Progestogen business.industry Mestranol Bilirubin Estrogens Megestrol General Medicine Jaundice medicine.disease Norethynodrel Rats Clinical research Endocrinology Liver Norethindrone Progestins medicine.symptom business Cholestasis of pregnancy Contraceptives Oral Hormone |
| Zdroj: | Nature New Biology. 234:110-111 |
| ISSN: | 2058-1092 0090-0028 |
| DOI: | 10.1038/newbio234110a0 |
| Popis: | ORAL contraceptives can cause a wide spectrum of hepatic abnormalities, from mild bromsulphthalein retention to cholestatic jaundice. In the United States it has been estimated that one woman in 10,000 taking oral contraceptives becomes jaundiced1. This jaundice is cholestatic in type and is similar to intrahepatic cholestasis of pregnancy. Most oral contraceptives are given as combinations of a synthetic oestrogen and progestogen or oestrogen given alone followed by a combination of oestrogen and progestogen. These substances can act on the liver, which plays a central part in their metabolism, to produce a variety of physiological and pathological effects. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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