The expanding roles of the Sda/Cad carbohydrate antigen and its cognate glycosyltransferase B4GALNT2

Autor: Dall'Olio, Fabio, Malagolini, Nadia, Chiricolo, Mariella, Trinchera, Marco, Harduin-Lepers, Anne, Harduin- Lepers, Anne
Přispěvatelé: Department of Experimental, Diagnostic and Specialty Medicine (DIMES) (DIMES), Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Department of Medicine Clinical and Experimental (DMCS), Universitá degli Studi dell’Insubria, Université Lille Nord de France (COMUE), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Universitá degli Studi dell’Insubria = University of Insubria [Varese] (Uninsubria), Université de Lille-Centre National de la Recherche Scientifique (CNRS), CNRS, Université Lille Nord de France, Lille1, Arcir 'dynamique' Région Nord-Pas de Calais, Università di Bologna [Bologna] (UNIBO), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA), Dall'olio F, Malagolini N, Chiricolo M, Trinchera M, Harduin-Lepers A, Université de Lille, University of Bologna/Università di Bologna, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], Université de Lille-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 2014
Předmět:
[SDV.BIO]Life Sciences [q-bio]/Biotechnology
Erythrocytes
Oligosaccharides
Histo-blood group antigens
[SDV.BID.SPT]Life Sciences [q-bio]/Biodiversity/Systematics
Phylogenetics and taxonomy
Bleeding disorders
Biochemistry
Fucose
Epigenetic control
chemistry.chemical_compound
0302 clinical medicine
MESH: Animals Blood Group Antigens/metabolism* Erythrocytes/metabolism* Humans N-Acetylgalactosaminyltransferases/metabolism* Oligosaccharides/metabolism
Cytotoxic T cell
Sialyl Lewis antigens
MESH: Animals
Bleeding disorder
ComputingMilieux_MISCELLANEOUS
0303 health sciences
biology
[SDV.BID.EVO]Life Sciences [q-bio]/Biodiversity/Populations and Evolution [q-bio.PE]
MESH: Erythrocytes
Sialyl Lewis antigen
[SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular Networks [q-bio.MN]
[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM]
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biomolecules [q-bio.BM]
3. Good health
Cell biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Blood Group Antigens
N-Acetylgalactosaminyltransferases
Histo-blood group antigen
Biophysics
[SDV.CAN]Life Sciences [q-bio]/Cancer
MESH: N-Acetylgalactosaminyltransferases
Natural killer cell
03 medical and health sciences
Antigen
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
Glycosyltransferase
medicine
Animals
Humans
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
[SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Biochemistry [q-bio.BM]
Molecular Biology
030304 developmental biology
MESH: Humans
MESH: Blood Group Antigens
Glycosyltransferases
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Sialyl-Lewis A
Muscular dystrophy
Sialic acid
Sialyl-Lewis X
chemistry
biology.protein
MESH: Oligosaccharides
Zdroj: BBA-Biochimica et Biophysica Acta
BBA-Biochimica et Biophysica Acta, Elsevier, 2013, 1840 (1), pp.443-53
BBA-Biochimica et Biophysica Acta, 2014, 1840 (1), pp.443-53. ⟨10.1016/j.bbagen.2013.09.036⟩
Biochimica et Biophysica Acta (BBA)-General Subjects
Biochimica et Biophysica Acta (BBA)-General Subjects, Elsevier, 2014, 1840 (1), pp.443-453. ⟨10.1016/j.bbagen.2013.09.036⟩
BBA-Biochimica et Biophysica Acta, 2013, 1840 (1), pp.443-53
Biochimica et Biophysica Acta (BBA)-General Subjects, 2014, 1840 (1), pp.443-453. ⟨10.1016/j.bbagen.2013.09.036⟩
ISSN: 0006-3002
0304-4165
DOI: 10.1016/j.bbagen.2013.09.036⟩
Popis: International audience; BACKGROUND:The histo-blood group antigens are carbohydrate structures present in tissues and body fluids, which contribute to the definition of the individual immunophenotype. One of these, the Sd(a) antigen, is expressed on the surface of erythrocytes and in secretions of the vast majority of the Caucasians and other ethnic groups.SCOPE OF REVIEW:We describe the multiple and unsuspected aspects of the biology of the Sd(a) antigen and its biosynthetic enzyme β1,4-N-acetylgalactosaminyltransferase 2 (B4GALNT2) in various physiological and pathological settings.MAJOR CONCLUSIONS:The immunodominant sugar of the Sd(a) antigen is a β1,4-linked N-acetylgalactosamine (GalNAc). Its cognate glycosyltransferase B4GALNT2 displays a restricted pattern of tissue expression, is regulated by unknown mechanisms - including promoter methylation, and encodes at least two different proteins, one of which with an unconventionally long cytoplasmic portion. In different settings, the Sd(a) antigen plays multiple and unsuspected roles. 1) In colon cancer, its dramatic down-regulation plays a potential role in the overexpression of sialyl Lewis antigens, increasing metastasis formation. 2) It is involved in the lytic function of murine cytotoxic T lymphocytes. 3) It prevents the development of muscular dystrophy in various dystrophic murine models, when overexpressed in muscular fibers. 4) It regulates the circulating half-life of the von Willebrand factor (vWf), determining the onset of a bleeding disorder in a murine model.GENERAL SIGNIFICANCE:The expression of the Sd(a) antigen has a wide impact on the physiology and the pathology of different biological systems.
Databáze: OpenAIRE
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