Synthesis and neuroleptic activity of N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfonamidobenzamide s

Autor:	Shiro Kida, Teruo Shiomi, Katsumi Hirose, Masaru Ogata, Hiroshi Matsumoto, Masami Eigyo
Rok vydání:	1984
Předmět:	chemistry.chemical_classification Pyrrolidines Stereochemistry Chemistry medicine.drug_class Biological activity Carboxamide Sulfonamide Dopamine receptor blockade Mice Dogs Dopamine receptor Drug Discovery Benzamides medicine Molecular Medicine Animals Sulpiride medicine.drug Antipsychotic Agents
Zdroj:	Journal of medicinal chemistry. 27(9)
ISSN:	0022-2623
Popis:	A series of some novel N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamides involving replacement of the sulfamoyl group in sulpiride with a sulfonamido group was synthesized and tested for dopamine receptor blockade. In comparison with sulpiride, several compounds were considerably more potent than sulpiride as dopamine receptor blockers. The structure-activity relationships are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90412584dfb875e44214e8e7649a191 https://pubmed.ncbi.nlm.nih.gov/6147414 Zobrazit plný text záznamu