Investigating Different Mechanisms of Action in Combination Therapy for Influenza
| Autor: | Thalia Rodriguez, Kelli Melville, Hana M. Dobrovolny |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Drug Combination therapy media_common.quotation_subject 030106 microbiology Drug resistance Antiviral mechanism Bioinformatics combination therapy 03 medical and health sciences Combined treatment Medicine Pharmacology (medical) Original Research media_common Pharmacology business.industry lcsh:RM1-950 mathematical modeling Limiting antiviral 3. Good health 030104 developmental biology lcsh:Therapeutics. Pharmacology Action (philosophy) business influenza Viral load mechanism of action |
| Zdroj: | Frontiers in Pharmacology, Vol 9 (2018) Frontiers in Pharmacology |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2018.01207/full |
| Popis: | Combination therapy for influenza can have several benefits, from reducing the emergence of drug resistant virus strains to decreasing the cost of antivirals. However, there are currently only two classes of antivirals approved for use against influenza, limiting the possible combinations that can be considered for treatment. However, new antivirals are being developed that target different parts of the viral replication cycle, and their potential for use in combination therapy should be considered. The role of antiviral mechanism of action in the effectiveness of combination therapy has not yet been systematically investigated to determine whether certain antiviral mechanisms of action pair well in combination. Here, we use a mathematical model of influenza to model combination treatment with antivirals having different mechanisms of action to measure peak viral load, infection duration, and synergy of different drug combinations. We find that antivirals that lower the infection rate and antivirals that increase the duration of the eclipse phase perform poorly in combination with other antivirals. |
| Databáze: | OpenAIRE |
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