The effect of the plasma n-3/n-6 polyunsaturated fatty acid ratio on the dietary LDL phenotype transformation - insights from the LIPGENE study
| Autor: | Carmen Marin, Jolene Mc Monagle, Audrey C. Tierney, Pablo Perez-Martinez, Jadwiga Hartwich, Catherine Defoort, Paweł Wołkow, Helen M. Roche, Lukasz Partyka, Jose Lopez-Miranda, Aldona Dembinska-Kiec, Malgorzata Malczewska Malec |
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| Rok vydání: | 2008 |
| Předmět: |
Apolipoprotein E
Adult Male medicine.medical_specialty Lipoproteins Matched-Pair Analysis Blood lipids Critical Care and Intensive Care Medicine Insulin resistance Internal medicine Fatty Acids Omega-6 Blood plasma Fatty Acids Omega-3 medicine Centrifugation Density Gradient Humans Diet Fat-Restricted Unsaturated fatty acid Aged chemistry.chemical_classification Metabolic Syndrome Nutrition and Dietetics business.industry Hypertriglyceridemia Middle Aged medicine.disease Atherosclerosis Dietary Fats Lipids Lipoproteins LDL Endocrinology Phenotype Treatment Outcome chemistry lipids (amino acids peptides and proteins) Female Metabolic syndrome business Polyunsaturated fatty acid |
| Zdroj: | Clinical nutrition (Edinburgh, Scotland). 28(5) |
| ISSN: | 1532-1983 |
| Popis: | Summary Background & aims LDL phenotype B is associated with obesity, insulin resistance, hypertriglyceridemia and oxidative stress. The effect of plasma n-3/n-6 PUFA ratio on LDL phenotype transformation was investigated. Methods Patients with metabolic syndrome (n = 99) received one of four isocaloric diets: (A) High-fat (38% energy) SFA-rich diet (HSFA); (B) High-fat (38% energy), MUFA-rich diet (HMUFA); (C), low-fat (LF) (28% energy), high-complex carbohydrate diet with 1.24 g/d oleic sunflower oil (LFHCC) and (D): low-fat (28% energy), high-complex carbohydrate diet, with 1.24 g/d LC n-3 PUFA (LFHCC n-3) for 12 weeks. Analysis of plasma lipid profile and LDL phenotype was done pre- and post-interventions. Results Post-dietary change of LDL density was a main effect observed in all groups. LFHCC n-3 and HFMUFA diets resulted in favorable alteration of LDL phenotype from B to A and decreased LDL density. In contrast, increased LDL density was observed in HSFA and LFHCC groups. The plasma pre-n3/n6 PUFA, Apo E change and pre-Apo CIII/CII ratios explained in 65% the post-dietary change of LDL density in diet LFHCC n-3 consumers. Conclusions Study demonstrates efficacy of dietary n-3 PUFA to modify pro-atherogenic to less atherogenic LDL phenotype in patients with metabolic syndrome. Study identifier at ClinicalTrials.gov was NCT00429195. |
| Databáze: | OpenAIRE |
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