Complementary effects of adenosine and angiotensin II in hypoxemia-induced renal dysfunction in the rabbit
Autor: | Frédéric Huet, Anne Prévot, Jean-Pierre Guignard, Jean-Bernard Gouyon, D S Semama |
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Rok vydání: | 2002 |
Předmět: |
Male
medicine.medical_specialty Adenosine Indoles Vasodilator Agents Renal function Angiotensin-Converting Enzyme Inhibitors Kidney Function Tests Adenosine receptor antagonist General Biochemistry Genetics and Molecular Biology Renal Circulation Theophylline Internal medicine medicine Animals Vasoconstrictor Agents General Pharmacology Toxicology and Pharmaceutics Hypoxia biology urogenital system Chemistry Angiotensin II Inulin Angiotensin-converting enzyme General Medicine Perindoprilat Filtration fraction medicine.anatomical_structure Endocrinology Renal blood flow Vascular resistance biology.protein Kidney Diseases Rabbits Blood Gas Analysis |
Zdroj: | Life Sciences. 71:779-787 |
ISSN: | 0024-3205 |
Popis: | The acute renal effects of hypoxemia and the ability of the co-administration of an angiotensin converting enzyme inhibitor (perindoprilat) and an adenosine receptor antagonist (theophylline) to prevent these effects were assessed in anesthetized and mechanically-ventilated rabbits. Renal blood flow (RBF) and glomerular filtration rate (GFR) were determined by the clearances of para-aminohippuric acid and inulin, respectively. Each animal acted as its own control. In 8 untreated rabbits, hypoxemia induced a significant drop in mean blood pressure (-12 +/- 2%), GFR (-16 +/- 3%) and RBF (-12 +/- 3%) with a concomitant increase in renal vascular resistance (RVR) (+ 18 +/- 5%), without changes in filtration fraction (FF) (-4 +/- 2%). These results suggest the occurrence of both pre- and postglomerular vasoconstriction during the hypoxemic stress. In 7 rabbits pretreated with intravenous perindoprilat (20 microg/kg), the hypoxemia-induced changes in RBF and RVR were prevented. FF decreased significantly (-18 +/- 2%), while the drop in GFR was partially blunted. These results could be explained by the inhibition of the angiotensin-mediated efferent vasoconstriction by perindoprilat. In 7 additional rabbits, co-administration of perindoprilat and theophylline (1 mg/kg) completely prevented the hypoxemia-induced changes in RBF (+ 11 +/- 3%) and GFR (+ 2 +/- 3%), while RVR decreased significantly (-14 +/- 3%). Since adenosine and angiotensin II were both shown to participate, at least in part, in the renal changes induced by hypoxemia, the beneficial effects of perindoprilat and theophylline in this model could be mediated by complementary actions of angiotensin II and adenosine on the renal vasculature. |
Databáze: | OpenAIRE |
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