Comparison of the Biologic Activity of Porcine and Semisynthetic Human Insulins Using the Glucose-controlled Insulin Infusion System in Insulin-dependent Diabetes
| Autor: | B Worcester, Tuxen D, Heyendal R, Ascher Ms, M A Charles, A Szekeres, K M Walsh |
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| Rok vydání: | 1983 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Swine Endocrinology Diabetes and Metabolism medicine.medical_treatment Artificial pancreas Insulin infusion Insulin Infusion Systems Diabetes mellitus Internal medicine Diabetes Mellitus Internal Medicine medicine Animals Humans Insulin Porcine pancreas Threonine Advanced and Specialized Nursing business.industry Middle Aged medicine.disease Endocrinology Insulin dependent diabetes Metabolic control analysis Drug Evaluation Female business |
| Zdroj: | Diabetes Care. 6:193-196 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.6.2.193 |
| Popis: | Semisynthetic human insulin is prepared from porcine pancreas by chemical methods involving the substitution of porcine insulin B-30 alanine with threonine. To compare the effectiveness of porcine and semisynthetic human insulins, eight insulin-dependent diabeticpatients were evaluated during two separate periods using a glucose-controlled insulin infusion system. During each 36-h period, patients received either porcine or semisynthetichuman insulin. Patients ingested mixed meals. The mean daily insulin requirements for porcine and semisynthetic human insulins were 84 ± 9 U and 85 ± 6 U (± SEM), respectively (P = NS). Mean blood glucose values were similar at 95 ±1 mg/dl for porcine and 101 ± 3 mg/dl with semisynthetic human insulin (P = NS). Prior metabolic control or insulin antibody levels did not correlate with intravenous insulin requirements. These studies indicate that semisynthetic human insulin is as effective as porcine insulin in maintaining near-normal blood glucose control in short-term intravenous studies using artificial pancreas techniques in insulin-dependent diabetes. |
| Databáze: | OpenAIRE |
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