Lnc00892 competes with c-Jun to block NCL transcription, reducing the stability of RhoA/RhoC mRNA and impairing bladder cancer invasion
| Autor: | Liping Shen, Ning Zhang, Yuanmei Zhang, Honglei Jin, Haishan Huang, Zhenni Lin, Yongyong Lu, Jiheng Xu, Yixin Chang, Ning Sun, Shuwei Ren |
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| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
RHOA Proto-Oncogene Proteins c-jun RhoC Mice Nude Apoptosis urologic and male genital diseases Metastasis Mice Biomarkers Tumor Tumor Cells Cultured Genetics medicine Animals Humans Neoplasm Invasiveness Neoplasm Metastasis Molecular Biology Cell Proliferation Messenger RNA Bladder cancer biology c-jun RNA-Binding Proteins Phosphoproteins medicine.disease Xenograft Model Antitumor Assays female genital diseases and pregnancy complications Long non-coding RNA Gene Expression Regulation Neoplastic Urinary Bladder Neoplasms rhoC GTP-Binding Protein biology.protein Cancer research Female RNA Long Noncoding rhoA GTP-Binding Protein Nucleolin |
| Zdroj: | Oncogene. 40:6579-6589 |
| ISSN: | 1476-5594 0950-9232 |
| DOI: | 10.1038/s41388-021-02033-8 |
| Popis: | Metastasis of bladder cancer is a complex process and has been associated with poor clinical outcomes. However, the mechanisms of bladder cancer metastasis remain largely unknown. The present study found that the long noncoding RNA lnc00892 was significantly downregulated in bladder cancer tissues, with low lnc00892 expression associated with poor prognosis of bladder cancer patients. Lnc00892 significantly inhibited the migration, invasion, and metastasis of bladder cancer cells in vitro and in vivo. In-depth analysis showed that RhoA/C acted downstream of lnc00892 to inhibit bladder cancer metastasis. Mechanistically, lnc00892 reduces nucleolin gene transcription by competitively binding the promoter of nucleolin with c-Jun, thereby inhibiting nucleolin-mediated stabilization of RhoA/RhoC mRNA. Taken together, these findings provide novel insights into understanding the mechanisms of bladder cancer metastasis and suggest that lnc00892 can serve as a potential therapeutic target in patients with invasive bladder cancer. |
| Databáze: | OpenAIRE |
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