Swine model of in-stent stenosis in the iliac artery evaluating the serial time course

Autor: Kenjiro Konno, Nobuhito Saito, Ayumi Horikawa, Akira Iijima, Minoru Tanaka, Terumitsu Hasebe, Osamu Ishikawa, Koki Takahashi
Rok vydání: 2018
Předmět:
medicine.medical_specialty
Time Factors
Swine
Original
medicine.medical_treatment
Constriction
Pathologic
030204 cardiovascular system & hematology
Iliac Artery
experimental study
General Biochemistry
Genetics and Molecular Biology
intravascular ultrasound
swine model
03 medical and health sciences
0302 clinical medicine
medicine.artery
Catheterization
Peripheral
Intravascular ultrasound
Animals
Medicine
cardiovascular diseases
030212 general & internal medicine
Stage (cooking)
Ultrasonography
Interventional
Iliac artery
Hyperplasia
General Veterinary
medicine.diagnostic_test
business.industry
Stent
General Medicine
medicine.disease
in-stent stenosis
Internal iliac artery
Disease Models
Animal
Stenosis
Carotid Arteries
Time course
Swine
Miniature
Stents
Animal Science and Zoology
Radiology
Tunica Intima
business
Zdroj: Experimental Animals
ISSN: 1881-7122
1341-1357
Popis: The aim of this study was to propose a new animal model evaluating the serial time course of in-stent stenosis by repeated carotid artery catheterization in the same animal. 16 bare-metal stents were implanted in the normal external and internal iliac artery of 8 miniature pigs. Repeated measurements were performed in the same animal every 2 weeks for 12 weeks through carotid artery catheterization. The time course and peak neointimal proliferation were evaluated by intravascular ultrasound. Health of all animals was assessed by clinical and hematological examinations. As a result, 7 times of carotid artery catheterization was performed per pig, but all animals remained healthy without both any complications and hematological inflammatory abnormalities. The time course of neointimal proliferation of each stent was observed from the stage of hyperplasia to partial regression. The peak neointimal proliferation varied from 6 to 12 weeks despite implantation of identical stents using the same deployment method. In conclusion, repeated carotid artery catheterization to the same animal is feasible without animal health deterioration. This model should be useful to evaluate the time course of neointimal proliferation after stent deployment in preclinical study.
Databáze: OpenAIRE
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