Swine model of in-stent stenosis in the iliac artery evaluating the serial time course
Autor: | Kenjiro Konno, Nobuhito Saito, Ayumi Horikawa, Akira Iijima, Minoru Tanaka, Terumitsu Hasebe, Osamu Ishikawa, Koki Takahashi |
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Rok vydání: | 2018 |
Předmět: |
medicine.medical_specialty
Time Factors Swine Original medicine.medical_treatment Constriction Pathologic 030204 cardiovascular system & hematology Iliac Artery experimental study General Biochemistry Genetics and Molecular Biology intravascular ultrasound swine model 03 medical and health sciences 0302 clinical medicine medicine.artery Catheterization Peripheral Intravascular ultrasound Animals Medicine cardiovascular diseases 030212 general & internal medicine Stage (cooking) Ultrasonography Interventional Iliac artery Hyperplasia General Veterinary medicine.diagnostic_test business.industry Stent General Medicine medicine.disease in-stent stenosis Internal iliac artery Disease Models Animal Stenosis Carotid Arteries Time course Swine Miniature Stents Animal Science and Zoology Radiology Tunica Intima business |
Zdroj: | Experimental Animals |
ISSN: | 1881-7122 1341-1357 |
Popis: | The aim of this study was to propose a new animal model evaluating the serial time course of in-stent stenosis by repeated carotid artery catheterization in the same animal. 16 bare-metal stents were implanted in the normal external and internal iliac artery of 8 miniature pigs. Repeated measurements were performed in the same animal every 2 weeks for 12 weeks through carotid artery catheterization. The time course and peak neointimal proliferation were evaluated by intravascular ultrasound. Health of all animals was assessed by clinical and hematological examinations. As a result, 7 times of carotid artery catheterization was performed per pig, but all animals remained healthy without both any complications and hematological inflammatory abnormalities. The time course of neointimal proliferation of each stent was observed from the stage of hyperplasia to partial regression. The peak neointimal proliferation varied from 6 to 12 weeks despite implantation of identical stents using the same deployment method. In conclusion, repeated carotid artery catheterization to the same animal is feasible without animal health deterioration. This model should be useful to evaluate the time course of neointimal proliferation after stent deployment in preclinical study. |
Databáze: | OpenAIRE |
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