| Autor: |
Nuri Tutar, Burcu Acar Cinleti, Göksel Güven, Nazire Ates Ayhan, Seda Yilmaz, Kamil Inci, Ahmet Firat, Jale Bengi Celik, Yeliz Bilir, Jülide Ergil, Gülseren Elay, Melda Turkoglu, Zuhal Gullu, Deniz Aral Ozbek, Begüm Ergan, Müge Aydoğdu, Ezgi Ozyilmaz, Tugce Mengi, Meltem Simsek, Irem Akin Sen, Bilgin Comert, Emre Karakoc, Ayca Gumus, Avşar Zerman, Recep Civan Yüksel, Ferhan Demirer Aydemir, Cenk Kirakli, Pervin Hanci, Neriman Defne Altintas, Serpil Öcal, İskender Kara, Leyla Talan, Şahin Temel, Ismail Hakki Akbudak, Türkay Akbaş, Firdevs Tugba Bozkurt, Ummu Gulsum Yuksel, Emre Aydin, Kemal Tolga Saracoglu, Ramazan Ulu, Kursat Gundogan, Ali Ümit Esbah, Mehmet Çağatay Gürkök, Arzu Topeli, Ibrahim Hakki Tor, Ebru Ortaç Ersoy, Taha Koray Sahin, Asli Acikgoz, Murat Sungur, Esma Eren, Fatma Yıldırım, Sema Sarı, Canan Balci, Burcin Halacli |
| Rok vydání: |
2021 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-150961/v1 |
| Popis: |
Background: There are limited data on long-term outcome and mortality predictors of COVID-19 from different parts of the world. The aim of this study was to determine risk factors of 90-day mortality in critically-ill patients infected with SARS-CoV-2 in Turkish ICUs. Methods: This multicenter, retrospective study was performed in 26 ICUs in Turkey. All patients with confirmed SARS-CoV2 infection, requiring more than 24 hours of ICU follow-up were included in the study. Demographics, clinical characteristics, laboratory variables, respiratory support, treatment types, and survival data were recorded. Results: A total of 421 patients were included in the study. The median age was 67 (IQR: 57-76) years, and 251 patients (59.6%) were men. 90-day mortality rate was 55.1%. Factors independently associated with 90-day mortality were receiving invasive mechanical ventilation (HR 4.09 [95% CI: 2.20-7.63]), admission lactate level > 2 mmol/L (2.78 [1.93-4.01]), age ≥ 60 years (2.45 [1.48-4.06)]), having cardiac arrhythmia during ICU stay (2.01 [1.27-3.20]), receiving vasopressor treatment (1.94 [1.32-2.84]), positive fluid balance of ≥ 600 ml/per day during ICU follow-up (1.68 [1.21-2.34]), admission PaO2/FiO2 ratio of ≤ 150 mmHg (1.66 [1.18-2.32], and baseline ECOG score ≥ 1 (1.42 [1.00-2.02]. Conclusion: This study has shown that long-term mortality was high in critically-ill COVID-19 patients in Turkish ICUs. Invasive mechanical ventilation, high lactate level, older age, presence of cardiac arrhythmia, need for vasopressor treatment, positive fluid balance, severe hypoxemia and not having fully-active performance were related with mortality. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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