Ag@MOF-loaded chitosan nanoparticle and polyvinyl alcohol/sodium alginate/chitosan bilayer dressing for wound healing applications
| Autor: | Yanxin Li, Guohui Wang, Shaoxiang Lee, Yuqi Zheng, Xin Zhang, Feifan Du, Dong Wang, Wenqiao Meng, Meng Zhang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Male
Silver Biocompatibility Alginates Metal Nanoparticles Nanoparticle 02 engineering and technology Biochemistry Polyvinyl alcohol Cell Line Chitosan Mice 03 medical and health sciences chemistry.chemical_compound Anti-Infective Agents Structural Biology medicine Animals Molecular Biology Metal-Organic Frameworks Skin 030304 developmental biology Mice Inbred BALB C Wound Healing 0303 health sciences Bilayer fungi Hydrogels General Medicine 021001 nanoscience & nanotechnology Bandages Anti-Bacterial Agents Chemical engineering chemistry Polyvinyl Alcohol Swelling medicine.symptom 0210 nano-technology Antibacterial activity Wound healing |
| Zdroj: | International Journal of Biological Macromolecules. 175:481-494 |
| ISSN: | 0141-8130 |
| DOI: | 10.1016/j.ijbiomac.2021.02.045 |
| Popis: | In this paper, Ag-Metal−organic framework loaded chitosan nanoparticles (0.1%Ag@MOF/1.5%CSNPs) and polyvinyl alcohol/sodium alginate/chitosan (PACS) were used as the upper and lower layers to successfully prepare a bilayer composite dressing for wound healing. The performance of bilayer dressing was evaluated. The lower layer (PACS) had uniform pore size distribution, good water retention, swelling, water vapor permeability, and biocompatibility while PACS had almost no antibacterial activity. The upper layer (Ag@MOF/CSNPs) possessed excellent antibacterial activity and poor biocompatibility. As the upper layer, it can avoid direct contact with the skin and inhibit microbial invasion. In addition, the bilayer can adhere to a large number of red blood cells and platelets, promoting blood coagulation and cell proliferation. Ag@MOF, CSNPs, Ag@MOF/CSNPs and bilayer showed antibacterial activity in ascending order, due to the synergistic antibacterial action of the upper and lower layer. In vivo evaluation showed that both bilayer and PACS could significantly accelerate the wound healing, and the bilayer dressing showed more complete re-epithelialization with less inflammatory cells. In summary, this new bilayer composite is an ideal dressing for accelerating wound healing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect