The effect of gadolinium DTPA on tissue water compartments in slow- and fast-twitch rabbit muscles
| Autor: | Robert V. Mulkern, Tamas Sandor, I. Kofi Adzamli, Ferenc A. Jolesz, Alan R. Bleier |
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| Rok vydání: | 1989 |
| Předmět: |
Gadolinium DTPA
Time Factors Fast twitch muscle Contrast Media Gadolinium In Vitro Techniques Organometallic Compounds medicine Extracellular Animals Radiology Nuclear Medicine and imaging Lagomorpha Tissue water medicine.diagnostic_test biology Chemistry Muscles Skeletal muscle Magnetic resonance imaging Rabbit (nuclear engineering) Anatomy Pentetic Acid biology.organism_classification Magnetic Resonance Imaging Rats medicine.anatomical_structure Biophysics Extracellular Space Perfusion |
| Zdroj: | Magnetic Resonance in Medicine. 11:172-181 |
| ISSN: | 1522-2594 0740-3194 |
| DOI: | 10.1002/mrm.1910110205 |
| Popis: | Proton T2 relaxation and its biexponential components have been determined in rabbit skeletal muscle in the presence and absence of GdDTPA. The effect of GdDTPA, which distributes only in the extracellular space, was greatest in the longer-relaxing T2 component (T22). A 27% reduction in T22 was measured for slow-twitch (red) muscle and 17% for fast-twitch (white) muscle, consistent with the larger extracellular space of the former. Magnetic resonance images demonstrated apparent contrast between red and white rabbit muscles. This contrast was instantaneously enhanced by administration of GdDTPA and returned to near normal levels after approximately 30 min. These functional changes in tissue contrast are consistent with differences in blood perfusion and biological water compartmentation between fast- and slow-twitch skeletal muscles. |
| Databáze: | OpenAIRE |
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