Swietenine extracted from Swietenia relieves myocardial hypertrophy induced by isoprenaline in mice
| Autor: | Yanfang Yu, Feng Chen, Jiacheng Wang, Juejin Wang, Guanhong Xu, Qian Weichun, Liu Shoubai, Pingxi Xiao, Zhengsheng Mao, Kai Li, Jingjing Ding, Youjia Yu, Chunyan Chu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Limonins
Male Cell Survival Health Toxicology and Mutagenesis Cardiomegaly 010501 environmental sciences Management Monitoring Policy and Law Pharmacology Cell Enlargement Toxicology 01 natural sciences Muscle hypertrophy Cell Line 03 medical and health sciences Mice 0302 clinical medicine Western blot In vivo Diabetes mellitus Isoprenaline medicine Animals Myocytes Cardiac Meliaceae Protein kinase B 0105 earth and related environmental sciences medicine.diagnostic_test business.industry Plant Extracts Myocardium Isoproterenol Heart General Medicine Organ Size medicine.disease In vitro Rats Swietenia macrophylla 030220 oncology & carcinogenesis Seeds business medicine.drug |
| Zdroj: | Environmental toxicologyREFERENCES. 35(12) |
| ISSN: | 1522-7278 |
| Popis: | As a traditional plant medicine in tropical areas, Swietenia macrophylla seeds are usually applied for some chronic diseases, including hypertension, diabetes, and so on. Few studies have been carried out to identify the effective elements in seed extract and their indications. In this study, we first investigated the functions of the swietenine, an extract from S. macrophylla seeds, using a model of myocardial hypertrophy induced by isoprenaline (ISO). At cellular level, H9c2 cell hypertrophy was also established through the treatment with ISO. The cardiac pathological remodeling was evaluated by echocardiography and histological analysis. Western blot and RT-qPCR were used to detect the expression of possible hypertrophy-promoting genes. Here, our results indicated that swietenine remarkably attenuated ISO-induced myocardial hypertrophy in vivo and in vitro. Moreover, Akt phosphorylation, ANP and BNP mRNA expression were efficiently decreased. Based on these findings, we concluded that swietenine might be a promising anti-hypertrophic agent against cardiac hypertrophy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text