Effects of mianserin and ketanserin on lordosis behavior after systemic treatment or infusion into the ventromedial nucleus of the hypothalamus
| Autor: | Marjay Caldarola-Pastuszka, Lynda Uphouse, Amy Wolf, Lucy Colon, Amy Cox |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Ketanserin Lordosis Ovariectomy Posture Mianserin Injections chemistry.chemical_compound Sexual Behavior Animal Internal medicine medicine Animals Molecular Biology Progesterone Estradiol business.industry General Neuroscience Brain medicine.disease Lordosis behavior Rats Inbred F344 Rats Ventromedial nucleus of the hypothalamus Endocrinology chemistry Hypothalamus Ventromedial Hypothalamic Nucleus Vagina Estradiol benzoate Ovariectomized rat Female Neurology (clinical) Serotonin Proestrus Serotonin Antagonists business Developmental Biology medicine.drug |
| Zdroj: | Brain research. 718(1-2) |
| ISSN: | 0006-8993 |
| Popis: | The effects of the 5-HT 2A/2C antagonists, mianserin and ketanserin, were investigated in proestrous rats and in ovariectomized rats hormonally primed with estradiol benzoate and progesterone. Drugs were administered systemically or by infusion into the vicinity of the ventromedial nucleus of the hypothalamus (VMN). By both routes of administration, inhibition of lordosis behavior was seen following treatment with the 5-HT 2A/2C antagonists, but the magnitude of the decline was smaller in proestrous than in hormone-primed, ovariectomized rats. The results of these studies are discussed in terms of the dual role of serotonin in the control of female sexual behavior. |
| Databáze: | OpenAIRE |
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