Molecular subtypes of invasive breast cancer: correlation between PET/computed tomography and MRI findings
| Autor: | Sebnem Orguc, Feray Aras, Meliha Akin, Ali Riza Kandiloglu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Computed tomography Breast Neoplasms 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences 0302 clinical medicine Breast cancer Positron Emission Tomography Computed Tomography Female patient medicine Effective diffusion coefficient Humans Radiology Nuclear Medicine and imaging Neoplasm Invasiveness Aged Retrospective Studies medicine.diagnostic_test business.industry General Medicine Metabolic tumor volume Luminal a Middle Aged medicine.disease Magnetic Resonance Imaging Tumor Burden 030220 oncology & carcinogenesis Female Nuclear medicine business Mri findings |
| Zdroj: | Nuclear medicine communications. 41(8) |
| ISSN: | 1473-5628 |
| Popis: | Objective The aim of the study was to investigate the diagnostic value of fluorodeoxyglucose-18 (FDG)-PET/computed tomography (CT) and MRI parameters in determining the molecular subtypes of invasive breast cancer. Methods Data from 55 primary invasive breast cancer masses in 51 female patients who underwent pre-treatment PET/CT and MRI scans, and histopathological diagnosis at the authors' center were retrospectively reviewed. The relationship between FDG-PET/CT and MRI parameters, including maximum and mean standard uptake values (SUVmax and SUVmean, respectively), mean metabolic index (MImean) and metabolic tumor volume (MTV) values obtained from FDG-PET, and shape, margin, internal contrast-enhancement characteristics, kinetic curve types, functional tumor volume (FTV), apparent diffusion coefficient (ADC) values obtained from MRI was evaluated. Subsequently, differences among molecular subtypes (i.e. luminal A, luminal B, c-erbB-2 positive, and triple-negative) in terms of PET/CT and MRI parameters were evaluated. Results The luminal B subtype of invasive breast cancer had higher SUVmax and SUVmean (P = 0.002 and P = 0.017, respectively) values than the luminal A subtype. In addition, the triple-negative subtype had a higher SUVmax (P = 0.028) than the luminal A subtype. There was a statistically significant positive correlation between pathological tumor volume (PTV) and SUVmean (P = 0.019, r = 0.720). SUVmax and ADC were negatively correlated (P = 0.001; r = -0.384). A very strong positive correlation was detected between MTV and FTV (P = 0.000; r = 0.857), and between MTV and PTV (P = 0.006, r = 0.796), and between FTV and PTV (P = 0.006, r = 0.921). Conclusion Results of the present study suggest that SUVmax was superior to MRI findings in predicting molecular subtypes and that MRI was superior to PET/CT in predicting PTV. |
| Databáze: | OpenAIRE |
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