Small and medium sized HDL particles are protectively associated with coronary calcification in a cross-sectional population-based sample

Autor: Hisham Nassar, James D. Otvos, Chobufo Muchi Ditah, Dorith Shaham, Ronit Sinnreich, Jeremy D. Kark
Rok vydání: 2015
Předmět:
0301 basic medicine
Male
medicine.medical_specialty
Magnetic Resonance Spectroscopy
Population
Coronary Artery Disease
030204 cardiovascular system & hematology
Probability sampling
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Particle Size
education
Coronary atherosclerosis
Lipoprotein cholesterol
Aged
education.field_of_study
business.industry
Myocardium
Cholesterol
HDL
nutritional and metabolic diseases
Calcinosis
Population based sample
Middle Aged
030104 developmental biology
Cross-Sectional Studies
Logistic Models
Treatment Outcome
Coronary artery calcification
Multivariate Analysis
Cardiology
lipids (amino acids
peptides
and proteins)
Female
Cardiology and Cardiovascular Medicine
business
Lipoproteins
HDL
Chd risk
Biomarkers
Linear trend
Zdroj: Atherosclerosis. 251
ISSN: 1879-1484
Popis: Background and aims Failure of trials to observe benefits by elevating plasma high-density lipoprotein cholesterol (HDL-C) has raised serious doubts about HDL-C's atheroprotective properties. We aimed to identify protective HDL biomarkers by examining the association of nuclear magnetic resonance (NMR) measures of total HDL-particle (HDL-P), large HDL-particle, and small and medium-sized HDL-particle (MS-HDL-P) concentrations and average HDL-particle size with coronary artery calcification (CAC), which reflects the burden of coronary atherosclerosis, and compare with that of HDL-C. Methods Using a cross-sectional design, 504 Jerusalem residents (274 Arabs and 230 Jews), recruited by population-based probability sampling, had HDL measured by NMR spectroscopy. CAC was determined by multidetector helical CT-scanning using Agatston scoring. Independent associations between the NMR measures and CAC (comparing scores ≥100 vs. Results Comparing tertile 3 vs. tertile 1, we observed protective associations of HDL-P (multivariable-adjusted OR 0.42, 95% CI 0.22–0.79, p linear trend = 0.002) and MS-HDL-P (OR 0.36, 95% CI 0.19–0.69), p linear trend = 0.006 with CAC, which persisted after further adjustment for HDL-C. HDL-C was not significantly associated with CAC (multivariable-adjusted OR 0.59, 95% CI 0.27–1.29 for tertiles 3 vs. 1, p linear trend = 0.49). Large HDL-P and average particle size (which are highly correlated; r = 0.83) were not associated with CAC: large HDL-P (OR 0.77, 95% CI 0.33–1.83, p linear trend = 0.29) and average HDL-P size (OR 0.72, 95% CI 0.35–1.48, p linear trend = 0.58). Conclusions MS-HDL-P represents a protective subpopulation of HDL particles. HDL-P and MS-HDL-P were more strongly associated with CAC than HDL-C. Based on the accumulating evidence, incorporation of MS-HDL-P or HDL-P into the routine prediction of CHD risk should be evaluated.
Databáze: OpenAIRE
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