Intron 22 factor VIII gene inversions in Argentine families with severe haemophilia A
| Autor: | C, De Brasi, M, Candela, M, Cermelj, I, Slavutsky, I, Larripa, R P, Bianco, M, De Tezanos Pinto |
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| Rok vydání: | 2000 |
| Předmět: |
Male
medicine.medical_specialty Population Haemophilia A Argentina Prenatal diagnosis Hemophilia A Gene Frequency stomatognathic system Isoantibodies Internal medicine medicine Humans education Gene Genetics (clinical) Chromosomal inversion Southern blot Family Health Genetics education.field_of_study Factor VIII business.industry Intron Hematology General Medicine medicine.disease Introns Blotting Southern Chromosome Inversion Female Severe haemophilia A DNA Probes business Polymorphism Restriction Fragment Length |
| Zdroj: | Haemophilia. 6:21-22 |
| ISSN: | 1351-8216 |
| DOI: | 10.1046/j.1365-2516.2000.00365.x |
| Popis: | Intron 22 factor VIII gene inversion (Inv22) is the most common mutation causing severe haemophilia A (SHA). We studied Inv22 in 34 SHA affected families by Southern blotting. Data from the familial history of the disease and the inhibitor status were also included. We found Inv22 in 41 % of SHA Argentine families (35 % with type 1 and 6 % with type 2), in close agreement with previously reported series. No significant correlation between the inheritance (familiar or sporadic disease) and the presence of inversions was found. Our population showed 24 % of families included at least one hemophiliac with inhibitor. In families positive for Inv22, 29 % of patients developed inhibitor but this increased frequency was not statistically significant. In conclusion, analysis of Inv22 in SHA patients should be used as a first line method because it provides useful and secure information for carrier detection and prenatal diagnosis in a high percentage of cases. |
| Databáze: | OpenAIRE |
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