Single-cell analyses uncover granularity of muscle stem cells
| Autor: | Alexander Y.T. Lin, John Saber, Michael A. Rudnicki |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Muscle tissue
Satellite Cells Skeletal Muscle Population Cell Review Cell fate determination Muscle Development General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Single-cell analysis medicine Humans single-cell analysis General Pharmacology Toxicology and Pharmaceutics Muscle Skeletal education 030304 developmental biology satellite cells cell fate 0303 health sciences education.field_of_study General Immunology and Microbiology biology Cell Differentiation Articles General Medicine biology.organism_classification medicine.anatomical_structure Satellite (biology) Granularity heterogeneity Stem cell Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| Popis: | Satellite cells are the main muscle-resident cells responsible for muscle regeneration. Much research has described this population as being heterogeneous, but little is known about the different roles each subpopulation plays. Recent advances in the field have utilized the power of single-cell analysis to better describe and functionally characterize subpopulations of satellite cells as well as other cell groups comprising the muscle tissue. Furthermore, emerging technologies are opening the door to answering as-yet-unresolved questions pertaining to satellite cell heterogeneity and cell fate decisions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|