Decreased risk of liver and intrahepatic cancer in non-H. pylori-infected perforated peptic ulcer patients with truncal vagotomy: a nationwide study
| Autor: | Chia Hao Hsu, Chia-Wei Tzeng, Chih-Hsin Muo, Han-Tsung Cheng, Shih Chi Wu, Yu-Chun Wang |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Science Peptic medicine.medical_treatment Taiwan Diseases Gastroenterology Pyloroplasty Article Helicobacter Infections Cohort Studies Young Adult 03 medical and health sciences Medical research 0302 clinical medicine Vagotomy Truncal Internal medicine medicine Humans Propensity Score Cancer Aged Multidisciplinary Helicobacter pylori business.industry Incidence Liver Neoplasms Hazard ratio Middle Aged medicine.disease Vagotomy Confidence interval Oncology Risk factors 030220 oncology & carcinogenesis Peptic Ulcer Perforation Propensity score matching Medicine Female 030211 gastroenterology & hepatology business Viral hepatitis |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) Scientific Reports |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-021-95142-z |
| Popis: | The vagal nervous system is central to the physiological responses and systemic diseases of the liver. We evaluated the subsequent risk of liver and intrahepatic cancer (HCC/ICC) in non-H. pylori (HP)-infected perforated peptic ulcer (PPU) patients with and without vagotomy. Hospitalized PPU patients who underwent simple closure or truncal vagotomy/pyloroplasty (TVP) in the National Health Insurance Research Database from 2000 to 2008 were enrolled. The exclusion criteria included: (1) Multiple surgeries for PPU were received at the same admission; (2) Any cancer history; (3) Previous peptic ulcer-associated surgery; (4) HP infection history; (5) Viral hepatitis infection history; (6) Follow-up duration |
| Databáze: | OpenAIRE |
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