Synthesis of Novel Spiro-Tetrahydroquinoline Derivatives and Evaluation of Their Pharmacological Effects on Wound Healing
| Autor: | Ke Wang, Yeong Jiunn Jang, Yan An Lin, Wenwei Lin, Yang Chang Wu, Juan-Cheng Yang, Yan Cheng Liou |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Keratinocytes
Male Models Molecular spiro-tetrahydroquinoline 1 3-Indandione one-pot reaction QH301-705.5 wound healing 010402 general chemistry 01 natural sciences Catalysis Article Inorganic Chemistry chemistry.chemical_compound Mice tetrahydroquinoline Animals Humans Spiro Compounds Physical and Theoretical Chemistry Biology (General) Molecular Biology QD1-999 Spectroscopy 010405 organic chemistry Organic Chemistry Stereoisomerism General Medicine Combinatorial chemistry 0104 chemical sciences Computer Science Applications Mice Inbred C57BL Chemistry 1 3-indandione chemistry One pot reaction Quinolines Wound healing Excision wound |
| Zdroj: | International Journal of Molecular Sciences Volume 22 Issue 12 International Journal of Molecular Sciences, Vol 22, Iss 6251, p 6251 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22126251 |
| Popis: | A highly diastereoselective method for the synthesis of novel spiro-tetrahydroquinoline derivatives is reported here, using a one-pot reaction method. All compounds were characterized by 1H-nuclear magnetic resonance (NMR) and mass spectroscopy, and their stereo configurations were confirmed by X-ray analysis. These activities of these derivatives were then tested in human keratocyte cells. The responses of cells to treatment with selected compounds were studied using scratch analysis, and the compounds were tested in a mouse excision wound model. Three of the derivatives demonstrated significant wound-healing activities. |
| Databáze: | OpenAIRE |
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