Upregulation of C-X-C chemokine receptor type 1 expression is associated with late-stage gastric adenocarcinoma
| Autor: | Kuan Song Wang, Zhihong Chen, Wan Ming Hu, Yu Wu Liu, Jun Yu, Jing He Li, Chang Wu, Qin Lai Liu, Jun Pu Wang, Ji Fang Wen, Geng Qiu Luo, Bai Hua Luo |
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| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Oncogene Microvascular Density Articles General Medicine Cell cycle Biology Molecular biology Sporadic Gastric Adenocarcinoma Chemokine receptor Immunology and Microbiology (miscellaneous) Downregulation and upregulation medicine Immunohistochemistry Immunostaining |
| Zdroj: | Experimental and Therapeutic Medicine. 4:55-60 |
| ISSN: | 1792-1015 1792-0981 |
| Popis: | Chemokine receptors play multiple roles in the development and progression of various tumor types. The aim of this study was to examine C-X-C chemokine receptor type 1 (CXCR1) protein expression in gastric adenocarcinoma and to investigate the clinical implications of CXCR1 upregulation. Expression of CXCR1 protein in 83 specimens of sporadic gastric adenocarcinoma and their corresponding non-neoplastic mucosa obtained by gastrectomy was assayed using immunohistochemistry. The intensity of immunostaining in tumor tissue was considered strong when tumor tissue staining was more intense than in the corresponding non-neoplastic mucosa; the intensity was null when staining was weaker in the tumor than in the corresponding non-neoplastic mucosa; and the intensity was weak when staining was similar in both tissues. Microvascular density in tumor tissue and its corresponding non-neoplastic mucosa was measured using monoclonal antibody against CD34. A strong correlation was observed between elevated CXCR1 protein expression and tumor stage (P |
| Databáze: | OpenAIRE |
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