Health-related quality of life in Parkinson’s: impact of ‘off’ time and stated treatment preferences
| Autor: | James Cooper, Andrew Lloyd, Charlotte E Kosmas, Emily J Lloyd, Emma McIntosh, Karissa Johnston, Helen T. Smith, Cicely Kerr |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Gerontology medicine.medical_specialty Activities of daily living Discrete choice experiment Choice Behavior Antiparkinson Agents Levodopa 03 medical and health sciences 0302 clinical medicine Quality of life Surveys and Questionnaires medicine Humans Off time Aged Health related quality of life 030503 health policy & services Public health Public Health Environmental and Occupational Health Parkinson Disease Odds ratio Middle Aged United Kingdom Italy Spain Plasma concentration Quality of Life Female France 0305 other medical science Psychology 030217 neurology & neurosurgery |
| Zdroj: | Quality of Life Research. 25:1505-1515 |
| ISSN: | 1573-2649 0962-9343 |
| Popis: | Long-term levodopa therapy and related fluctuating plasma concentrations are associated with between-dose periods of ‘off time’ resulting in substantial variation in symptoms and functioning throughout the day in people with Parkinson’s (PwP). PwP across UK, France, Spain and Italy completed an online survey to explore: the impact of ‘off time’ on (1) health-related quality of life (HRQL) and (2) on functioning and ability to undertake usual activities; (3) the value of ‘off time’ relative to other factors associated with Parkinson’s through a stated preference discrete choice experiment (SPDCE). In total, 305 PwP completed the online survey. Overall mean HRQL (utility) score was significantly lower for ‘off time’ (0.37) than for ‘on time’ (0.60). All attributes within the SPDCE were significant predictors of treatment choice, although increased duration of ‘on time’ (per hour per day: odds ratio (OR) = 1.40) and predictability of ‘off time’ to within 30 min (OR = 1.42) were valued most highly. ‘On time’ and predictability of ‘off time’ are highly valued by PwP. Due to substantial diurnal variation of Parkinson’s symptoms, standard patient-reported outcome (PRO) assessments may not adequately capture the impact of ‘off time’ on HRQL and participation in daily activities. |
| Databáze: | OpenAIRE |
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