Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes
| Autor: | Peter Erb, Manuel Battegay, Gilbert R. Kaufmann, Christoph Strub, Natasha Hansjee, Rainer Weber |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
CD4-Positive T-Lymphocytes Male Programmed cell death Apoptosis HIV Infections Biology CD8-Positive T-Lymphocytes Caspase 8 Virus Replication Peripheral blood mononuclear cell Cohort Studies Immunopathology Antiretroviral Therapy Highly Active Humans Pharmacology (medical) Aged T lymphocyte Middle Aged Infectious Diseases Phenotype Immunology HIV-1 Leukocytes Mononuclear Tumor necrosis factor alpha Female CD8 |
| Zdroj: | Journal of acquired immune deficiency syndromes (1999). 36(2) |
| ISSN: | 1525-4135 |
| Popis: | CD4 T-cell depletion in HIV-1 infection is partly the result of T-cell apoptosis. Spontaneous apoptosis (SA) and apoptosis markers Fas-associated death-domain-like IL-1 beta converting enzyme (FLICE)-like inhibitory protein (FLIP), Bcl-2, TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), TRAIL receptor 1, and Fas were determined in 55 HIV-1 infected persons treated with highly active antiretroviral therapy (HAART) for 48 months. Despite suppressive HAART, SA remained elevated. Increased SA of peripheral blood mononuclear cells (PBMCs) and CD8 T lymphocytes and increased TRAIL receptor 1 expression strongly predicted a poorer recovery of CD4 T-cell count. HAART did not significantly alter anti-or proapoptotic markers in cultured PBMCs and T lymphocytes. The significant relationship between residual T-lymphocyte apoptosis and CD4 T-cell recovery suggests that persistent apoptosis may impede immune restoration. |
| Databáze: | OpenAIRE |
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