Test-Retest and Interreader Reproducibility of Semiautomated Atlas-Based Analysis of Diffusion Tensor Imaging Data in Acute Cervical Spine Trauma in Adult Patients
| Autor: | Daniel J. Peterson, Jeffrey G. Jarvik, Daniel S. Hippe, Falgun H. Chokshi, Mahmud Mossa-Basha, Aaron M. Rutman, Charles H. Bombardier, Maria Regina Reyes |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Adolescent Intraclass correlation Coefficient of variation Pyramidal Tracts 030218 nuclear medicine & medical imaging White matter Young Adult 03 medical and health sciences Atlases as Topic 0302 clinical medicine Fractional anisotropy Image Processing Computer-Assisted Humans Medicine Radiology Nuclear Medicine and imaging Gray Matter Spinal cord injury Aged Observer Variation Reproducibility business.industry Reproducibility of Results Middle Aged Spinal cord medicine.disease White Matter Spine Diffusion Tensor Imaging medicine.anatomical_structure Spinal Injuries Cervical Vertebrae Anisotropy Female Neurology (clinical) business Nuclear medicine 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a5334 |
| Popis: | BACKGROUND AND PURPOSE: DTI is a tool for microstructural spinal cord injury evaluation. This study evaluated the reproducibility of a semiautomated segmentation algorithm of spinal cord DTI. MATERIALS AND METHODS: Forty-two consecutive patients undergoing acute trauma cervical spine MR imaging underwent 2 axial DTI scans in addition to their clinical scan. The datasets were put through a semiautomated probabilistic segmentation algorithm that selected white matter, gray matter, and 24 individual white matter tracts. Regional and white matter tract volume, fractional anisotropy, and mean diffusivity values were calculated. Two readers performed the nonautomated steps to evaluate interreader reproducibility. The coefficient of variation and intraclass correlation coefficient were used to assess test-retest and interreader reproducibility. RESULTS: Of 42 patients, 30 had useable data. Test-retest reproducibility of fractional anisotropy was high for white matter as a whole (coefficient of variation, 3.8%; intraclass correlation coefficient, 0.93). Test-retest coefficient-of-variation ranged from 8.0%–18.2% and intraclass correlation coefficients from 0.47–0.80 across individual white matter tracts. Mean diffusivity metrics also had high test-retest reproducibility (white matter: coefficient-of-variation, 5.6%; intraclass correlation coefficient, 0.86) with coefficients of variation from 11.6%–18.3% and intraclass correlation coefficients from 0.57–0.74 across individual tracts, with better agreement for larger tracts. The coefficients of variation of fractional anisotropy and mean diffusivity both had significant negative relationships with white matter volume (26%–27% decrease for each doubling of white matter volume, P < .01). CONCLUSIONS: DTI spinal cord segmentation is reproducible in the setting of acute spine trauma, specifically for larger white matter tracts and total white or gray matter. |
| Databáze: | OpenAIRE |
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