Invertebrate Iridoviruses: A Glance over the Last Decade
| Autor: | Arzu Özgen, İkbal Agah İnce, Orhan Ozcan, Erin D. Scully, Ayca Zeynep Ilter-Akulke |
|---|---|
| Přispěvatelé: | Acibadem University Dspace |
| Rok vydání: | 2018 |
| Předmět: |
Gene Expression Regulation
Viral 0301 basic medicine Genes Viral 030106 microbiology lcsh:QR1-502 Virulence Genomics Review Proteomics Genome lcsh:Microbiology Host Specificity Iridovirus Viral Proteins 03 medical and health sciences proteomics Virology biology.animal genomics Animals Phylogeny Research Subject Categories::MEDICINE biology Host (biology) Virion Vertebrate Invertebrates Phenotype 030104 developmental biology Infectious Diseases classification Evolutionary biology invertebrate iridoviruses Identification (biology) |
| Zdroj: | Viruses Viruses, Vol 10, Iss 4, p 161 (2018) |
| Popis: | Members of the family Iridoviridae (iridovirids) are large dsDNA viruses that infect both invertebrate and vertebrate ectotherms and whose symptoms range in severity from minor reductions in host fitness to systemic disease and large-scale mortality. Several characteristics have been useful for classifying iridoviruses; however, novel strains are continuously being discovered and, in many cases, reliable classification has been challenging. Further impeding classification, invertebrate iridoviruses (IIVs) can occasionally infect vertebrates; thus, host range is often not a useful criterion for classification. In this review, we discuss the current classification of iridovirids, focusing on genomic and structural features that distinguish vertebrate and invertebrate iridovirids and viral factors linked to host interactions in IIV6 (Invertebrate iridescent virus 6). In addition, we show for the first time how complete genome sequences of viral isolates can be leveraged to improve classification of new iridovirid isolates and resolve ambiguous relations. Improved classification of the iridoviruses may facilitate the identification of genus-specific virulence factors linked with diverse host phenotypes and host interactions. |
| Databáze: | OpenAIRE |
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