Effects of cycloheximide on DNA and protein synthesis in rat liver

Autor:	R. G. O'Dell, K. Tornheim, Leon Prosky
Rok vydání:	1969
Předmět:	Male Carbon Isotopes DNA Organ Size Cycloheximide Biology Molecular biology General Biochemistry Genetics and Molecular Biology Rats chemistry.chemical_compound chemistry Liver Rat liver Protein Biosynthesis Protein biosynthesis Animals RNA Injections Intraperitoneal
Zdroj:	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 131(2)
ISSN:	0037-9727
Popis:	SummaryCycloheximide markedly decreases protein synthesis (68%) at a time when RNA synthesis is only slightly inhibited. The DNA content of the liver increases with increasing dosage of the drug; animals treated with cycloheximide and having 1.5 times as many nuclei had twice as much DNA-P in their liver as control animals. The abrupt inhibition of protein synthesis contrasts with a gradual, dose-dependent rise in DNA-P and suggests a separation of these two effects of cycloheximide.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ecaeb7347eeab6529c95c7a21fcb4c https://pubmed.ncbi.nlm.nih.gov/5787143 Zobrazit plný text záznamu