Erythrocyte polyamine levels in human prostatic carcinoma
| Autor: | B. Cipolla, Martin La, Francois Guille, R. Havouis, V. Quemener, Bernard Lobel, J.-Ph. Moulinoux |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty Erythrocytes Spermidine Urology Prostatic Hyperplasia Spermine Adenocarcinoma chemistry.chemical_compound Prostate Internal medicine medicine Humans Chromatography High Pressure Liquid Aged business.industry Prostatic Neoplasms medicine.disease Red blood cell Prostate-specific antigen medicine.anatomical_structure Endocrinology chemistry Prostatic acid phosphatase Polyamine business |
| Zdroj: | The Journal of urology. 144(5) |
| ISSN: | 0022-5347 |
| Popis: | Abnormally high red blood cell polyamine levels were found in benign prostatic hyperplasia and in prostatic adenocarcinoma patients. In prostatic adenocarcinoma patients a relationship was noted between the importance of red blood cell spermidine and spermine concentrations, and the clinical stage of the disease (Whitmore classification). Considering prostatic adenocarcinoma patient populations, patients with metastases (groups 3 and 4) statistically differed from those without metastases (group 2). Furthermore, red blood cell polyamine level determination discriminated patients in the hormonal escape group (group 4) from those usually considered as hormone responsive (groups 2 and 3). No statistically significant correlation was observed between red blood cell polyamine levels and usual tumor markers (prostatic acid phosphatase and prostate specific antigen). These results confirmed that red blood cell polyamine levels must be considered as a circulating index of cell proliferation that might be of clinical importance during the long-term followup and treatment of prostatic adenocarcinoma patients. |
| Databáze: | OpenAIRE |
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