Circulating 25-hydroxyvitamin D level and prognosis of lung cancer patients: A systematic review and meta-analysis
| Autor: | Tong-Jie Gu, Dan-Fei Zhou, Jian-Da Huang, Jun Ying, Sheng-Wen Shao, Zhi-Lin Hu, Yan-Ping Xie, Chao-Hui Dong |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Lung Neoplasms Sensitivity and Specificity 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor medicine Overall survival Humans Radiology Nuclear Medicine and imaging Prospective Studies Vitamin D Lung cancer Retrospective Studies business.industry Hazard ratio Retrospective cohort study Hematology General Medicine Prognosis medicine.disease Surgery 030104 developmental biology 030220 oncology & carcinogenesis Meta-analysis business |
| Zdroj: | Bulletin du Cancer. 104:675-682 |
| ISSN: | 0007-4551 |
| Popis: | Summary Background Previous studies suggested a possible influence of circulating 25-hydroxyvitamin D [25(OH)D] level on the prognosis of lung cancer patients, but conflicting findings were reported. A systematic review and meta-analysis was thus conducted to comprehensively assess the influence of circulating 25(OH)D level on the prognosis of lung cancer patients. Methods Prospective or retrospective cohort studies assessing the influence of circulating 25(OH)D level on the prognosis of lung cancer patients were considered eligible. Hazard Ratios (HR) were pooled using meta-analysis. Results Eight studies with 2166 lung cancer patients were included. Meta-analysis of unadjusted HRs from four studies showed low circulating 25(OH)D level was significantly correlated with poor overall survival in lung cancer (HR = 1.30, 95%CI 1.08–1.55, P = 0.004). Meta-analysis of adjusted HRs from eight studies suggested that low circulating 25(OH)D level was not significantly correlated with poor overall survival (HR = 1.25; P = 0.13). However, sensitivity analysis suggested an obvious change in the pooled HRs when excluding single study by turns. When the study by Liu et al. was omitted, low circulating 25(OH)D level was significantly correlated with poor overall survival (HR = 1.34; P = 0.04). Conclusion The present systematic review and meta-analysis suggested a correlation between low circulating 25(OH)D level and poor overall survival in lung cancer. More studies are needed to further validate the finding above. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|