Direct assembly of multiply oxygenated carbon chains by decarbonylative radical–radical coupling reactions
| Autor: | Masanori Nagatomo, Kengo Masuda, Masayuki Inoue |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Ornithine
Carbon chain Maitotoxin Free Radicals 010405 organic chemistry Carbohydrate chemistry General Chemical Engineering Oxocins Stereoisomerism macromolecular substances General Chemistry 010402 general chemistry 01 natural sciences Carbon Coupling reaction 0104 chemical sciences Oxygen Sugar derivatives chemistry.chemical_compound Aminoglycosides chemistry Quantum Theory Organic chemistry Marine Toxins Hikizimycin |
| Zdroj: | Nature Chemistry. 9:207-212 |
| ISSN: | 1755-4349 1755-4330 |
| DOI: | 10.1038/nchem.2639 |
| Popis: | Pentoses and hexoses contain more than three oxygen-bearing stereocentres and are ideal starting materials for the synthesis of multiply oxygenated natural products such as sagittamide D, maitotoxin and hikizimycin. Here we demonstrate new radical-radical homocoupling reactions of sugar derivatives with minimal perturbation of their chiral centres. The radical exchange procedure using Et |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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