Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders
| Autor: | Antoon T.M. Willemsen, Andreas Otte, David Vállez García, Rudi Dierckx, Janine Doorduin |
|---|---|
| Přispěvatelé: | Radiology and nuclear medicine, Molecular Neuroscience and Ageing Research (MOLAR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
WDQ
Whiplash Disability Questionnaire PAG periaqueductal gray 2000-2010 TASK-FORCE BMI body mass index mA milliamperes Precuneus lcsh:Medicine GEE Generalized Estimating Equations 030218 nuclear medicine & medical imaging 0302 clinical medicine PROGNOSTIC-FACTORS HEADACHE Whiplash Medicine Non-painful electrical stimulation Default mode network lcsh:R5-920 NK1 neurokinin 1 Brain NDI Neck Disability Index General Medicine NECK PAIN WAD whiplash associated disorders CT computed tomography medicine.anatomical_structure Neuropsychological questionnaires RESTING STATE Cerebral blood flow Cerebrovascular Circulation FWHM full width at half maximum Anesthesia Whiplash associated disorders lcsh:Medicine (General) psychological phenomena and processes Research Paper Adult Positron emission tomography LAMINA-I MNI Montreal Neurological Institute Thalamus BRAIN SPECT Neuroimaging HOSPITAL ANXIETY Insular cortex PET positron emission tomography General Biochemistry Genetics and Molecular Biology HADS Hospital Anxiety and Depression Scale Young Adult 03 medical and health sciences SVC small volume correction cWAD chronic whiplash associated disorders Humans Whiplash Injuries VAS visual analog scale SwE sandwich estimator SE standard error Resting state fMRI business.industry lcsh:R gCBF global cerebral blood flow B unstandardized coefficient medicine.disease CI confidence interval DEPRESSION SCALE SPM statistical parametric mapping DMN default mode network nervous system Case-Control Studies Positron-Emission Tomography Posterior cingulate Chronic Disease SPECT single-photon emission computed tomography SD standard deviation business MRI magnetic resonance imaging Neuroscience 030217 neurology & neurosurgery TALAIRACH ATLAS rCBF regional cerebral blood flow |
| Zdroj: | EBioMedicine, 10, 249-257. Elsevier BV EBioMedicine, 10, 249-257. ELSEVIER SCIENCE BV Vállez García, D, Doorduin, J, Willemsen, A T M, Dierckx, R A J O & Otte, A 2016, ' Altered Regional Cerebral Blood Flow in Chronic Whiplash Associated Disorders ', EBioMedicine, vol. 10, pp. 249-257 . https://doi.org/10.1016/j.ebiom.2016.07.008 EBioMedicine, Vol 10, Iss C, Pp 249-257 (2016) EBioMedicine |
| ISSN: | 2352-3964 |
| Popis: | There is increasing evidence of central hyperexcitability in chronic whiplash-associated disorders (cWAD). However, little is known about how an apparently simple cervical spine injury can induce changes in cerebral processes. The present study was designed (1) to validate previous results showing alterations of regional cerebral blood flow (rCBF) in cWAD, (2) to test if central hyperexcitability reflects changes in rCBF upon non-painful stimulation of the neck, and (3) to verify our hypothesis that the missing link in understanding the underlying pathophysiology could be the close interaction between the neck and midbrain structures. For this purpose, alterations of rCBF were explored in a case-control study using H215O positron emission tomography, where each group was exposed to four different conditions, including rest and different levels of non-painful electrical stimulation of the neck. rCBF was found to be elevated in patients with cWAD in the posterior cingulate and precuneus, and decreased in the superior temporal, parahippocampal, and inferior frontal gyri, the thalamus and the insular cortex when compared with rCBF in healthy controls. No differences in rCBF were observed between different levels of electrical stimulation. The alterations in regions directly involved with pain perception and interoceptive processing indicate that cWAD symptoms might be the consequence of a mismatch during the integration of information in brain regions involved in pain processing. Highlights • Differences of rCBF were explored by PET in cWAD patients and healthy volunteers exposed to four conditions. • Changes in rCBF were observed in cWAD patients in regions involved in pain perception and interoceptive sensory information. • These changes might be the consequence of a mismatch in the integration of interoceptive stimuli in pain processing regions. In the past, published work on chronic whiplash-associated disorders (cWAD) has caused much confusion and discussion, yet functional imaging methods such as positron emission tomography (PET) have demonstrated a variety of different significant alterations in the perfusion or glucose utilization of the brain. The present study, using PET and the perfusion marker, H215O, is a step forward in whiplash research. It shows changes in perfusion in regions directly involved in pain perception and interoceptive sensory information, such as the insular cortex, precuneus, and posterior cingulate, indicating a mismatch in the integration of interoceptive information in pain processing brain regions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|